Difference between revisions of "NagA"

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* '''Kinetic information:''' K(M): 1.4 mM {{PubMed|14343123}}  
 
* '''Kinetic information:''' K(M): 1.4 mM {{PubMed|14343123}}  
  
* '''Domains:'''  
+
* '''[[Domains]]:'''  
  
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
+
* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
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* '''Regulation:'''  
 
* '''Regulation:'''  
** induced in the presence of N-acetylglucosamine ([[NagR]]) {{PubMed|21602348,14343123}}  
+
** induced in the presence of N-acetylglucosamine ([[NagR]]) {{PubMed|24673833,21602348,14343123}}  
 
** repressed by glucose (2.9-fold) ([[CcpA]]) [http://www.ncbi.nlm.nih.gov/pubmed/12850135 PubMed]   
 
** repressed by glucose (2.9-fold) ([[CcpA]]) [http://www.ncbi.nlm.nih.gov/pubmed/12850135 PubMed]   
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
** [[NagR]]: transcription repression {{PubMed|21602348}}
+
** [[NagR]]: transcription repression {{PubMed|24673833,21602348}}
 
** [[CcpA]]: transcription repression [http://www.ncbi.nlm.nih.gov/pubmed/12850135 PubMed]  
 
** [[CcpA]]: transcription repression [http://www.ncbi.nlm.nih.gov/pubmed/12850135 PubMed]  
  
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=References=
 
=References=
<pubmed>10627040, 14343123,12850135 6174502, 14557261 23667565 21602348 23876412</pubmed>
+
<pubmed>10627040, 14343123,12850135 6174502, 14557261 23667565 21602348 24673833,23876412</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 10:51, 31 March 2014

  • Description: N-acetylglucosamine-6-phosphate deacetylase

Gene name nagA
Synonyms
Essential no
Product N-acetylglucosamine-6-phosphate deacetylase
Function N-acetylglucosamine utilization
Gene expression levels in SubtiExpress: nagA
Metabolic function and regulation of this protein in SubtiPathways:
nagA
MW, pI 42 kDa, 5.276
Gene length, protein length 1188 bp, 396 aa
Immediate neighbours hprK, nagB
Sequences Protein DNA DNA_with_flanks
Genetic context
NagA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
NagA expression.png















Categories containing this gene/protein

cell wall degradation/ turnover, utilization of specific carbon sources

This gene is a member of the following regulons

CcpA regulon, NagR regulon

The gene

Basic information

  • Locus tag: BSU35010

Phenotypes of a mutant

  • no growth on N-acetylglucosamine PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate (according to Swiss-Prot)
  • Protein family: nagA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information: K(M): 1.4 mM PubMed
  • Modification:
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]

Additional information

Expression and regulation

  • Regulation:
    • induced in the presence of N-acetylglucosamine (NagR) PubMed
    • repressed by glucose (2.9-fold) (CcpA) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References