Difference between revisions of "ParB"
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| − | * '''Description:''' chromosome positioning near the pole and transport through the polar septum / antagonist of [[Soj]]-dependent inhibition of sporulation initiation <br/><br/> | + | * '''Description:''' chromosome positioning near the pole and transport through the polar septum / antagonist of [[Soj]]-dependent inhibition of [[sporulation]] initiation <br/><br/> |
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=== Additional information=== | === Additional information=== | ||
| − | |||
| − | |||
| − | |||
=The protein= | =The protein= | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' inhibits [[Soj]] dimerization and concomitant DNA-binding activity by stimulating Soj ATPase activity {{PubMed|21235642}} | + | * '''Catalyzed reaction/ biological activity:''' |
| + | ** inhibits [[Soj]] dimerization and concomitant DNA-binding activity by stimulating Soj ATPase activity {{PubMed|21235642}} | ||
| + | ** recruits the condensin complex to the DNA origin region {{PubMed|24440393}} | ||
* '''Protein family:''' parB family (according to Swiss-Prot) | * '''Protein family:''' parB family (according to Swiss-Prot) | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| Line 151: | Line 150: | ||
<pubmed> 22934648 </pubmed> | <pubmed> 22934648 </pubmed> | ||
== Original publications == | == Original publications == | ||
| − | <pubmed>17462018 16677298 12562803, 10852876, 10482533, 9506522, 8071208, 17932079 19450517 21235642 9663676,11532141,19450516,15659156,18854156,9159397,8866474,9778525,16925562,1900505,9364919,9701805,12950914,,14651647, 19450517, 19450516, 14563866 23475963 21911367</pubmed> | + | <pubmed>17462018 16677298 12562803, 10852876, 10482533, 9506522, 8071208, 17932079 19450517 21235642 9663676,11532141,19450516,15659156,18854156,9159397,8866474,9778525,16925562,1900505,9364919,9701805,12950914,,14651647, 19450517, 19450516, 14563866 23475963 21911367 24440393</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 15:28, 16 February 2014
- Description: chromosome positioning near the pole and transport through the polar septum / antagonist of Soj-dependent inhibition of sporulation initiation
| Gene name | spo0J |
| Synonyms | parB, spo0JB |
| Essential | no |
| Product | site-specific DNA-binding protein |
| Function | chromosome positioning before asymmetric septation,
specifying its orientation, and imposing directionality on its subsequent transport through the septum; required for sporulation (antagonist of Soj-dependent inhibition of sporulation initiation) |
| Gene expression levels in SubtiExpress: spo0J | |
| Interactions involving this protein in SubtInteract: Spo0J | |
| MW, pI | 32 kDa, 8.417 |
| Gene length, protein length | 846 bp, 282 aa |
| Immediate neighbours | yyaC, soj |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
DNA condensation/ segregation, sporulation/ other
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU40960
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: parB family (according to Swiss-Prot)
- Paralogous protein(s): Noc
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- Localization:
- chromosome centromer PubMed
Database entries
- Structure:
- UniProt: P26497
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
- Heath Murray, Centre for Bacterial Cell Biology, Newcastle, UK homepage
Your additional remarks
References
Reviews
Rodrigo Reyes-Lamothe, Emilien Nicolas, David J Sherratt
Chromosome replication and segregation in bacteria.
Annu Rev Genet: 2012, 46;121-43
[PubMed:22934648]
[WorldCat.org]
[DOI]
(I p)
Original publications
