PhrE

• Description: response regulator aspartate phosphatase (RapE) regulator, control of the phosphorelay
  
  

Gene name	phrE
Synonyms
Essential	no
Product	phosphatase (RapE) regulator
Function	control of sporulation initiation
Gene expression levels in SubtiExpress: phrE
Interactions involving this protein in SubtInteract: PhrE
Function and regulation of this protein in SubtiPathways: phrE
MW, pI	4 kDa, 8.863
Gene length, protein length	132 bp, 44 aa
Immediate neighbours	rapE, yqzI
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

phosphorelay, quorum sensing, Skin element, short peptides

This gene is a member of the following regulons

AbrB regulon, CcpA regulon, CodY regulon, ComA regulon, SigH regulon

The gene

Basic information

• Locus tag: BSU25840

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Additional information

• A mutation was found in this gene after evolution under relaxed selection for sporulation PubMed

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: phr family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O32025

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • rapE-phrE PubMed
  • phrE PubMed

• Expression browser: phrE PubMed

• Sigma factor:
  • phrE: SigA PubMed, SigH PubMed

• Regulation: repressed by glucose (10-fold) (CcpA) PubMed
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • ComA: transcription activation PubMed

• Regulatory mechanism:
  • CcpA: transcription repression
  • CodY: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: