RsbRD

• Description: probably part of the stressosome, negative regulator of SigB activity
  
  

Gene name	rsbRD
Synonyms	yqhA
Essential	no
Product	RsbR paralog
Function	control of SigB activity
Gene expression levels in SubtiExpress: rsbRD
Interactions involving this protein in SubtInteract: RsbRD
MW, pI	31 kDa, 5.089
Gene length, protein length	834 bp, 278 aa
Immediate neighbours	yqhB, trnSL-Gln1
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed 500px

Categories containing this gene/protein

sigma factors and their control, general stress proteins (controlled by SigB), membrane proteins, phosphoproteins

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

• Locus tag: BSU24760

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): RsbR, RsbRB, RsbRC, YtvA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Thr-181 by RsbT PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • RsbRD-RsbT PubMed
  • YtvA-RsbRD PubMed
  • component of the stressosome

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P54504

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: rsbRD (according to DBTBS)

• Expression browser: rsbRD PubMed

• Sigma factor: SigB PubMed

• Regulation:
  • expressed under stress conditions (SigB) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Adam Reeves, Luis Martinez, William Haldenwang
Expression of, and in vivo stressosome formation by, single members of the RsbR protein family in Bacillus subtilis.
Microbiology (Reading): 2010, 156(Pt 4);990-998
[PubMed:20019076] [WorldCat.org] [DOI] (I p)

Christine Eymann, Dörte Becher, Jörg Bernhardt, Katrin Gronau, Anja Klutzny, Michael Hecker
Dynamics of protein phosphorylation on Ser/Thr/Tyr in Bacillus subtilis.
Proteomics: 2007, 7(19);3509-26
[PubMed:17726680] [WorldCat.org] [DOI] (P p)

Boris Macek, Ivan Mijakovic, Jesper V Olsen, Florian Gnad, Chanchal Kumar, Peter R Jensen, Matthias Mann
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.
Mol Cell Proteomics: 2007, 6(4);697-707
[PubMed:17218307] [WorldCat.org] [DOI] (P p)

Tae-Jong Kim, Tatiana A Gaidenko, Chester W Price
A multicomponent protein complex mediates environmental stress signaling in Bacillus subtilis.
J Mol Biol: 2004, 341(1);135-50
[PubMed:15312768] [WorldCat.org] [DOI] (P p)

S Akbar, T A Gaidenko, C M Kang, M O'Reilly, K M Devine, C W Price
New family of regulators in the environmental signaling pathway which activates the general stress transcription factor sigma(B) of Bacillus subtilis.
J Bacteriol: 2001, 183(4);1329-38
[PubMed:11157946] [WorldCat.org] [DOI] (P p)

A Petersohn, J Bernhardt, U Gerth, D Höper, T Koburger, U Völker, M Hecker
Identification of sigma(B)-dependent genes in Bacillus subtilis using a promoter consensus-directed search and oligonucleotide hybridization.
J Bacteriol: 1999, 181(18);5718-24
[PubMed:10482513] [WorldCat.org] [DOI] (P p)