Difference between revisions of "HprT"
| Line 1: | Line 1: | ||
| − | * '''Description:''' hypoxanthine phosphoribosyltransferase <br/><br/> | + | * '''Description:''' [[trigger enzyme]],hypoxanthine phosphoribosyltransferase and part of a transcription activator<br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 12: | Line 12: | ||
|style="background:#ABCDEF;" align="center"| '''Product''' || hypoxanthine phosphoribosyltransferase | |style="background:#ABCDEF;" align="center"| '''Product''' || hypoxanthine phosphoribosyltransferase | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || purine salvage and interconversion | + | |style="background:#ABCDEF;" align="center"|'''Function''' || purine salvage and interconversion, control of ''[[ftsH]]'' expression |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU00680 hprT] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU00680 hprT] | ||
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/HprT HprT] | ||
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/purines_salvage_pathways.html Purine salvage], [http://subtiwiki.uni-goettingen.de/pathways/purine_biosynthesis.html Purine synthesis], [http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/purines_salvage_pathways.html Purine salvage], [http://subtiwiki.uni-goettingen.de/pathways/purine_biosynthesis.html Purine synthesis], [http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)]''' | ||
| Line 41: | Line 43: | ||
= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
{{SubtiWiki category|[[biosynthesis/ acquisition of nucleotides]]}}, | {{SubtiWiki category|[[biosynthesis/ acquisition of nucleotides]]}}, | ||
| + | {{SubtiWiki category|[[transcription factors and their control]]}}, | ||
{{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, V, W, X, Y)]]}}, | {{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, V, W, X, Y)]]}}, | ||
{{SubtiWiki category|[[essential genes]]}} | {{SubtiWiki category|[[essential genes]]}} | ||
| Line 46: | Line 49: | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
{{SubtiWiki regulon|[[SigM regulon]]}} | {{SubtiWiki regulon|[[SigM regulon]]}} | ||
| + | |||
| + | = The [[TilS-HprT regulon]] = | ||
| + | * ''[[ftsH]]'' | ||
=The gene= | =The gene= | ||
| Line 92: | Line 98: | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| + | ** [[TilS]]-[[HprT]], the complex activates transcription of ''[[ftsH]]'' {{PubMed|24001521}} | ||
* '''[[Localization]]:''' cytoplasm (according to Swiss-Prot) | * '''[[Localization]]:''' cytoplasm (according to Swiss-Prot) | ||
Revision as of 11:58, 11 September 2013
- Description: trigger enzyme,hypoxanthine phosphoribosyltransferase and part of a transcription activator
| Gene name | hprT |
| Synonyms | |
| Essential | yes PubMed |
| Product | hypoxanthine phosphoribosyltransferase |
| Function | purine salvage and interconversion, control of ftsH expression |
| Gene expression levels in SubtiExpress: hprT | |
| Interactions involving this protein in SubtInteract: HprT | |
| Metabolic function and regulation of this protein in SubtiPathways: Purine salvage, Purine synthesis, Nucleotides (regulation) | |
| MW, pI | 20 kDa, 4.603 |
| Gene length, protein length | 540 bp, 180 aa |
| Immediate neighbours | tilS, ftsH |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of nucleotides, transcription factors and their control, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes
This gene is a member of the following regulons
The TilS-HprT regulon
The gene
Basic information
- Locus tag: BSU00680
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
- Protein family: purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- inhibition of enzymatic activity by (p)ppGpp during the ´stringent response´PubMed
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 1J7J (from Salmonella typhimurium, 51% identity, 73% similarity)
- UniProt: P37472
- KEGG entry: [2]
- E.C. number: 2.4.2.8
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
