Difference between revisions of "Main Page"

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<big>'''Paper of the month: August 2013'''</big>  
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<big>'''Paper of the month: September 2013'''</big>  
* In cells, the concentration of ribonucleotides by far exceeds that of deoxyribonucleotides. This poses problems since the DNA polymerase incorporates one rNTP every 2.3 kb during [[DNA replication|chromosome replication]]. Now, [http://www.ncbi.nlm.nih.gov/pubmed/23882084 Yao et al.] investigated how these misincorporations  are repaired. The demonstrate that this repair is initiated by [[rnhB|RNase HII]] that nicks DNA at single rNMP residues to initiate replacement with dNMP.
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* Biofilms of ''B. subtilis'' consist of cells in a matrix made up of extracellular polysaccharides, the amyloid-like [[TasA]] protein, and the hydrophobic protein [[BslA]]. Now, [http://www.ncbi.nlm.nih.gov/pubmed/23904481 Hobley et al.] from the lab of [[Nicola Stanley-Wall]] determined the structure of [[BslA]] and found that the protein has an extremely hydrophobic cap domain that acts like a raincoat for the biofilm. The authors suggest that [[BslA]] is a bacterial hydrophobin.
* '''Relevant ''Subti''Wiki pages:'''  [[DNA replication]], [[DNA repair/ recombination|DNA repair]], ''[[rnhB]]'', ''[[rnhC]]'', ''[[mutS]]'', ''[[mutL]]''
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* '''Relevant ''Subti''Wiki pages:'''  [[Nicola Stanley-Wall]], [[biofilm formation]], [[BslA]]
<pubmed> 23882084 </pubmed>
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<pubmed> 23904481 </pubmed>
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* '''A comment on this paper:'''
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<pubmed> 23979433 </pubmed>
 
* [[Previous papers of the month]]
 
* [[Previous papers of the month]]
  

Revision as of 13:32, 2 September 2013

Welcome to SubtiWiki! - Bacillus subtilis annotation the "wiki" way!

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Paper of the month: September 2013

  • Biofilms of B. subtilis consist of cells in a matrix made up of extracellular polysaccharides, the amyloid-like TasA protein, and the hydrophobic protein BslA. Now, Hobley et al. from the lab of Nicola Stanley-Wall determined the structure of BslA and found that the protein has an extremely hydrophobic cap domain that acts like a raincoat for the biofilm. The authors suggest that BslA is a bacterial hydrophobin.
  • Relevant SubtiWiki pages: Nicola Stanley-Wall, biofilm formation, BslA

Laura Hobley, Adam Ostrowski, Francesco V Rao, Keith M Bromley, Michael Porter, Alan R Prescott, Cait E MacPhee, Daan M F van Aalten, Nicola R Stanley-Wall
BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm.
Proc Natl Acad Sci U S A: 2013, 110(33);13600-5
[PubMed:23904481] [WorldCat.org] [DOI] (I p)

  • A comment on this paper:


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News in SubtiWiki:

  • April 2013: SubtiWiki uses a new, faster Mediawiki platform! The times for page access are significantly reduced. Enjoy!
  • March 2013: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
  • October 2012: the essential genes have been categorized
  • September 2012: 300 mutant strains available at the BGSC were added to the corresponding gene pages
  • August 2012: SubtiExpress, the new compagnon of SubtiWiki devoted to gene expression is online! Try it out!
  • April 2012: Links for expression data under 104 different conditions (based on Nicolas et al., 2012) have been added to the expression section of the individual gene pages
  • April 2011: SubtInteract, a presentation of protein-protein interactions in B. subtilis, is online!
  • December 2010: SubtiCellPublisher allows the conversion of CellDesigner diagrams to navigatable presentations in the style of SubtiPathways
  • December 2010: all genes are linked to regulons, and the pages of the regulons provide an overview on all genes that are members of this specific regulon.
  • December 2010: all genes/proteins are linked to categories, and the pages of the categories provide an overview on all genes/proteins that are members of this specific category.


Genes (examples) Additional pages
spo0A SubtiPathways
glnA Lists of genes, proteins and RNAs
rny Categories
psdA Regulons
pckA methods
dnaA metabolism
rnpA protein-protein interactions
sigB genome-wide analyses
ptkA list of plasmids
mreC labs working on Bacillus
ccpA the people behind SubtiWiki
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Publications describing SubtiWiki and SubtiPathways: