Difference between revisions of "SndA"

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m (Jstuelk moved page YtnL to SndA: 23944997)
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* '''Description:''' unknown <br/><br/>
+
* '''Description:''' sulphur compound N-deacetylase, required for the conversion of S-methyl-cysteine to cysteine<br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"|'''Gene name'''
 
|style="background:#ABCDEF;" align="center"|'''Gene name'''
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|''ytnL''
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|''sndA''
 
|-
 
|-
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|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''hipO ''
+
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''hipO, ytnL ''
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
−
|style="background:#ABCDEF;" align="center"| '''Product''' || unknown
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|style="background:#ABCDEF;" align="center"| '''Product''' || sulphur compound N-deacetylase
 
|-
 
|-
−
|style="background:#ABCDEF;" align="center"|'''Function''' || unknown
+
|style="background:#ABCDEF;" align="center"|'''Function''' || utilization of S-methyl-cysteine
 
|-
 
|-
−
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU29290 ytnL]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU29290 sndA]
 
|-
 
|-
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/riboflavin.html Riboflavin / FAD]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/riboflavin.html Riboflavin / FAD]'''
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= [[Categories]] containing this gene/protein =
 
= [[Categories]] containing this gene/protein =
−
{{SubtiWiki category|[[proteins of unknown function]]}}
+
{{SubtiWiki category|[[sulfur metabolism]]}}
  
 
= This gene is a member of the following [[regulons]] =
 
= This gene is a member of the following [[regulons]] =
 
{{SubtiWiki regulon|[[CymR regulon]]}},
 
{{SubtiWiki regulon|[[CymR regulon]]}},
−
{{SubtiWiki regulon|[[YtlI regulon]]}},
+
{{SubtiWiki regulon|[[AscR regulon]]}},
 
[[Efp-dependent proteins]]
 
[[Efp-dependent proteins]]
  
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=Expression and regulation=
 
=Expression and regulation=
−
* '''Operon:''' ''[[ytmI]]-[[tcyJ]]-[[tcyK]]-[[tcyL]]-[[tcyM]]-[[tcyN]]-[[ytmO]]-[[ytnI]]-[[ytnJ]]-[[ribR]]-[[ytnL]]-[[ytnM]]'' {{PubMed|15668000}}
+
* '''Operon:''' ''[[snaA]]-[[tcyJ]]-[[tcyK]]-[[tcyL]]-[[tcyM]]-[[tcyN]]-[[cmoO]]-[[cmoI]]-[[cmoJ]]-[[ribR]]-[[sndA]]-[[ytnM]]'' {{PubMed|15668000}}
  
−
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ytnL_2999717_3000967_-1 ytnL] {{PubMed|22383849}}
+
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ytnL_2999717_3000967_-1 sndA] {{PubMed|22383849}}
  
 
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|15272571}}
 
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|15272571}}
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* '''Regulation:'''  
 
* '''Regulation:'''  
 
** repressed in the presence of cysteine ([[CymR]]) {{PubMed|16109943}}
 
** repressed in the presence of cysteine ([[CymR]]) {{PubMed|16109943}}
 +
** induced in the presence of S-methyl-cysteine ([[AscR]]) {{PubMed|23944997}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 
** [[CymR]]: transcription repression {{PubMed|16109943}}
 
** [[CymR]]: transcription repression {{PubMed|16109943}}
−
** [[YtlI]]: transcription activation {{PubMed|16109943}}  
+
** [[AscR]]: transcription activation {{PubMed|16109943}}  
  
 
* '''Additional information:'''
 
* '''Additional information:'''
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=References=
 
=References=
−
'''Additional publications:''' {{PubMed|15272571}}
+
<pubmed>16109943,15668000,15272571 23944997</pubmed>
−
<pubmed>16109943,15668000,</pubmed>
 
−
 
 
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 11:30, 18 August 2013

  • Description: sulphur compound N-deacetylase, required for the conversion of S-methyl-cysteine to cysteine

Gene name sndA
Synonyms hipO, ytnL
Essential no
Product sulphur compound N-deacetylase
Function utilization of S-methyl-cysteine
Gene expression levels in SubtiExpress: sndA
Metabolic function and regulation of this protein in SubtiPathways:
Riboflavin / FAD
MW, pI 45 kDa, 5.545
Gene length, protein length 1248 bp, 416 aa
Immediate neighbours ytnM, ribR
Sequences Protein DNA DNA_with_flanks
Genetic context
YtnL context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YtnL expression.png















Categories containing this gene/protein

sulfur metabolism

This gene is a member of the following regulons

CymR regulon, AscR regulon, Efp-dependent proteins

The gene

Basic information

  • Locus tag: BSU29290

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: peptidase M20 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

The gene was annotated in KEGG and MetaCyc as hippurate hydrolase EC 3.5.1.32. In Swiss-Prot it is marked as “uncharacterized hydrolase”. No literature/experimental evidence supporting ththeannotation was removed as of November 2009. PubMed

Expression and regulation

  • Regulation:
    • repressed in the presence of cysteine (CymR) PubMed
    • induced in the presence of S-methyl-cysteine (AscR) PubMed
  • Additional information:
    • translation is likely to require Efp due to the presence of several consecutive proline residues PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

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