Difference between revisions of "YabA"
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| − | * '''Description:''' tethers [[DnaA]] to the polymerase-clamp protein [[DnaN]] <br/><br/> | + | * '''Description:''' inhibitor of [[DnaA]] oligomerization, tethers [[DnaA]] to the polymerase-clamp protein [[DnaN]] <br/><br/> |
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** associates with the ''oriC'' region in a [[DnaA]]-dependent manner, this limits the amount of [[DnaA]] that can bind the ''oriC'' region {{PubMed|21895792}} | ** associates with the ''oriC'' region in a [[DnaA]]-dependent manner, this limits the amount of [[DnaA]] that can bind the ''oriC'' region {{PubMed|21895792}} | ||
** YabA inhibits co-operative DNA binding by [[DnaA]] {{PubMed|21895792}} | ** YabA inhibits co-operative DNA binding by [[DnaA]] {{PubMed|21895792}} | ||
| + | ** inhibits oligomerization and helix formation of [[DnaA]] {{PubMed|23909787}} | ||
* '''Protein family:''' yabA family (according to Swiss-Prot) | * '''Protein family:''' yabA family (according to Swiss-Prot) | ||
Revision as of 16:46, 8 August 2013
| Gene name | yabA |
| Synonyms | |
| Essential | no |
| Product | negative regulator of replication initiation |
| Function | positioning of DnaA |
| Gene expression levels in SubtiExpress: yabA | |
| Interactions involving this protein in SubtInteract: YabA | |
| MW, pI | 13 kDa, 6.065 |
| Gene length, protein length | 357 bp, 119 aa |
| Immediate neighbours | yaaT, yabB |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00330
Phenotypes of a mutant
strongly reduced growth rate in minimal medium PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: yabA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: leucine zipper
- Modification:
- Cofactor(s): Zn cluster
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P37542
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Philippe Noirot, Jouy-en-Josas, France Homepage
Alan Grossman, Cambridge, MA, USA Homepage
Your additional remarks
References
Reviews
Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura, Kazuyuki Fujimitsu
Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC.
Nat Rev Microbiol: 2010, 8(3);163-70
[PubMed:20157337]
[WorldCat.org]
[DOI]
(I p)
Original publications
