Difference between revisions of "ECF transporter"
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== The general components of the ECF transporters == | == The general components of the ECF transporters == | ||
* [[ybxA]] ATP-binding A1 protein (EcfA1) | * [[ybxA]] ATP-binding A1 protein (EcfA1) | ||
| + | * [[ybaE]] ATP-binding A2 protein (EcfA2) | ||
| + | * [[ybaF]] membrane-spanning T protein (EcfT) | ||
== The substrate-specific S components of the ECF transporters == | == The substrate-specific S components of the ECF transporters == | ||
| + | * [[RibU]]: uptake of riboflavin | ||
| + | * [[ThiT]]: uptake of thiamine | ||
| + | * [[YhfU]]: uptake of biotin | ||
| + | * [[TrpP]]: uptake of tryptophan | ||
== Important reviews and publications == | == Important reviews and publications == | ||
<pubmed>23584589 , 21135102, 20497229, </pubmed> | <pubmed>23584589 , 21135102, 20497229, </pubmed> | ||
Revision as of 15:07, 13 July 2013
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Contents
ECF transporters are required for the uptake of micronutrients such as cofactors (vitamins), metal ions, or amino acids. The transporters are composed of three general components (membrane spanning T protein und two ATP-hydrolyzing A proteins) and substrate-specific S proteins.
In B. subtilis, there are four known substrates for ECF transporters, riboflavin, thiamine, biotin, and tryptophan.
The general components of the ECF transporters
- ybxA ATP-binding A1 protein (EcfA1)
- ybaE ATP-binding A2 protein (EcfA2)
- ybaF membrane-spanning T protein (EcfT)
The substrate-specific S components of the ECF transporters
- RibU: uptake of riboflavin
- ThiT: uptake of thiamine
- YhfU: uptake of biotin
- TrpP: uptake of tryptophan
Important reviews and publications
Ke Xu, Minhua Zhang, Qin Zhao, Fang Yu, Hui Guo, Chengyuan Wang, Fangyuan He, Jianping Ding, Peng Zhang
Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis.
Nature: 2013, 497(7448);268-71
[PubMed:23584589]
[WorldCat.org]
[DOI]
(I p)
Josy ter Beek, Ria H Duurkens, Guus B Erkens, Dirk Jan Slotboom
Quaternary structure and functional unit of energy coupling factor (ECF)-type transporters.
J Biol Chem: 2011, 286(7);5471-5
[PubMed:21135102]
[WorldCat.org]
[DOI]
(I p)
Thomas Eitinger, Dmitry A Rodionov, Mathias Grote, Erwin Schneider
Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions.
FEMS Microbiol Rev: 2011, 35(1);3-67
[PubMed:20497229]
[WorldCat.org]
[DOI]
(I p)
