Difference between revisions of "Prs"
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=== Database entries === | === Database entries === | ||
| − | * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1IBS 1IBS] [http://www.rcsb.org/pdb/explore.do?structureId=1DKR 1DKR] | + | * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1IBS 1IBS] [http://www.rcsb.org/pdb/explore.do?structureId=1DKR 1DKR][http://www.rcsb.org/pdb/explore.do?structureId=1DKU 1DKU] |
* '''UniProt:''' [http://www.uniprot.org/uniprot/P14193 P14193] | * '''UniProt:''' [http://www.uniprot.org/uniprot/P14193 P14193] | ||
Revision as of 08:31, 10 July 2013
- Description: phosphoribosylpyrophosphate synthetase, universally conserved protein
| Gene name | prs |
| Synonyms | |
| Essential | yes PubMed |
| Product | phosphoribosylpyrophosphate synthetase |
| Function | phosphoribosylpyrophosphate synthesis (biosynthesis of histidine) |
| Gene expression levels in SubtiExpress: prs | |
| Interactions involving this protein in SubtInteract: Prs | |
| Metabolic function and regulation of this protein in SubtiPathways: Purine synthesis, Nucleotides (regulation), His, Murein recycling | |
| MW, pI | 34 kDa, 5.895 |
| Gene length, protein length | 951 bp, 317 aa |
| Immediate neighbours | gcaD, ctc |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, biosynthesis/ acquisition of nucleotides, essential genes, universally conserved proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00510
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
- Protein family: ribose-phosphate pyrophosphokinase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- subject to feedback inhibition by two end products of purine biosynthesis, adenosine 5'-diphosphate (ADP) and guanosine 5'-diphosphate (GDP) PubMed
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: P14193
- KEGG entry: [3]
- E.C. number: 2.7.6.1
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
