Difference between revisions of "RasP"
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| − | * '''Description:''' intramembrane protease, cleaves [[FtsL]] and [[RsiW]] as well as signal peptides after release of the secreted proteins<br/><br/> | + | * '''Description:''' intramembrane protease, cleaves [[FtsL]], [[RsiV]] and [[RsiW]] as well as signal peptides after release of the secreted proteins<br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 12: | Line 12: | ||
|style="background:#ABCDEF;" align="center"| '''Product''' || intramembrane protease | |style="background:#ABCDEF;" align="center"| '''Product''' || intramembrane protease | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || control of [[cell division]] and [[SigW]] activity | + | |style="background:#ABCDEF;" align="center"|'''Function''' || control of [[cell division]], and [[SigV]] and [[SigW]] activity |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU16560 rasP] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU16560 rasP] | ||
| Line 56: | Line 56: | ||
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
* defects in competence development, [[protein secretion]] and membrane protein production {{PubMed|23155385}} | * defects in competence development, [[protein secretion]] and membrane protein production {{PubMed|23155385}} | ||
| + | * mutants grow slower in liquid, are not competent, can’t activate [[SigW]], have [[cell division]] defects, and decreased long term survival {{PubMed|23687273}} | ||
=== Database entries === | === Database entries === | ||
| Line 70: | Line 71: | ||
* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| − | ** cleaves [[FtsL]] and [[RsiW]] | + | ** cleaves [[FtsL]], [[RsiV]] and [[RsiW]] |
** cleaves signal peptides after release of the secreted proteins {{PubMed|21810987}} | ** cleaves signal peptides after release of the secreted proteins {{PubMed|21810987}} | ||
| Line 90: | Line 91: | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| − | ** [[RasP]]-[[FtsL]] | + | ** [[RasP]]-[[FtsL]] |
| + | ** [[RasP]]-[[RsiW]] | ||
| + | ** [[RasP]]-[[RsiV]] {{PubMed|23687273}} | ||
* '''[[Localization]]:''' cell membrane [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed] | * '''[[Localization]]:''' cell membrane [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed] | ||
| Line 142: | Line 145: | ||
=References= | =References= | ||
==Reviews== | ==Reviews== | ||
| − | + | <pubmed> 20836086 23479438,22381678</pubmed> | |
| − | <pubmed> 20836086 </pubmed> | ||
==Original Publications== | ==Original Publications== | ||
| − | + | <pubmed>16899079,15130127,18599827,17020588,19889088 ,18763711, 20644139 21810987 23687273 23155385</pubmed> | |
| − | <pubmed>16899079,15130127,18599827,17020588,19889088 ,18763711, 20644139 21810987 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:38, 27 May 2013
- Description: intramembrane protease, cleaves FtsL, RsiV and RsiW as well as signal peptides after release of the secreted proteins
| Gene name | rasP |
| Synonyms | yluC |
| Essential | no |
| Product | intramembrane protease |
| Function | control of cell division, and SigV and SigW activity |
| Gene expression levels in SubtiExpress: rasP | |
| Interactions involving this protein in SubtInteract: RasP | |
| MW, pI | 46 kDa, 5.14 |
| Gene length, protein length | 1266 bp, 422 aa |
| Immediate neighbours | ispC, proS |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
cell division, proteolysis, sigma factors and their control, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU16560
Phenotypes of a mutant
- defects in competence development, protein secretion and membrane protein production PubMed
- mutants grow slower in liquid, are not competent, can’t activate SigW, have cell division defects, and decreased long term survival PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: peptidase M50B family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane PubMed
Database entries
- Structure:
- UniProt: O31754
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Thomas Wiegert, University of Bayreuth, Germany Homepage
Your additional remarks
References
Reviews
Original Publications
