LigD

• Description: confers dry-heat resistance to dormant spores PubMed, similar to ATP-dependent DNA ligase
  
  

Gene name	ykoU
Synonyms
Essential	no
Product	unknown
Function	non-homologous end joining DNA repair
Gene expression levels in SubtiExpress: ykoU
MW, pI	70 kDa, 6.646
Gene length, protein length	1833 bp, 611 aa
Immediate neighbours	ykoT, ykoV
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination, sporulation proteins

This gene is a member of the following regulons

SigG regulon, SpoVT regulon

The gene

Basic information

• Locus tag: BSU13400

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: C-terminal DNA ligase catalytic domain linked to an N-terminal polymerase domain PubMed

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O34398

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: ykoV-ykoU PubMed

• Expression browser: ykoU PubMed

• Sigma factor: SigG PubMed

• Regulation:
  • expressed during sporulation in the forespore (SigG, SpoVT) PubMed

• Regulatory mechanism:
  • SpoVT: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Stewart Shuman, Michael S Glickman
Bacterial DNA repair by non-homologous end joining.
Nat Rev Microbiol: 2007, 5(11);852-61
[PubMed:17938628] [WorldCat.org] [DOI] (I p)