Difference between revisions of "MetA"

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Revision as of 13:42, 16 May 2013

  • Description: homoserine O-succinyltransferase

Gene name metA
Synonyms metB
Essential no
Product homoserine O-succinyltransferase
Function biosynthesis of methionine
Gene expression levels in SubtiExpress: metA
Metabolic function and regulation of this protein in SubtiPathways:
Lys, Thr, Cys, Met & Sulfate assimilation
MW, pI 25 kDa, 6.414
Gene length, protein length 672 bp, 224 aa
Immediate neighbours bsaA, ugtP
Sequences Protein DNA DNA_with_flanks
Genetic context
MetA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MetA expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of amino acids cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

SigM regulon

The gene

Basic information

  • Locus tag: BSU21910

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine (according to Swiss-Prot) O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2GHR (from Bacillus cereus, 60% identity, 77% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon: metA (according to DBTBS)
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References