YxdM

• Description: ABC transporter (permease)
  
  

Gene name	yxdM
Synonyms
Essential	no
Product	ABC transporter (permease)
Function	export of toxic peptides
Gene expression levels in SubtiExpress: yxdM
Interactions involving this protein in SubtInteract: YxdM
MW, pI	70 kDa, 9.272
Gene length, protein length	1866 bp, 622 aa
Immediate neighbours	yxeA, yxdL
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

YxdJ regulon

The gene

Basic information

• Locus tag: BSU39630

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ABC-4 integral membrane protein family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: YxdL-YxdM PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P42424

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: yxdL-yxdM-yxeA PubMed

• Expression browser: yxdM PubMed

• Sigma factor:

• Regulation:
  • induced by a cationic antimicrobial peptide, LL-37 (YxdJ) 21078927 PubMed

• Regulatory mechanism:
  • YxdJ: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Stéphanie Coumes-Florens, Céline Brochier-Armanet, Annick Guiseppi, François Denizot, Maryline Foglino
A new highly conserved antibiotic sensing/resistance pathway in firmicutes involves an ABC transporter interplaying with a signal transduction system.
PLoS One: 2011, 6(1);e15951
[PubMed:21283517] [WorldCat.org] [DOI] (I e)

Pascale Joseph, Annick Guiseppi, Alexei Sorokin, François Denizot
Characterization of the Bacillus subtilis YxdJ response regulator as the inducer of expression for the cognate ABC transporter YxdLM.
Microbiology (Reading): 2004, 150(Pt 8);2609-2617
[PubMed:15289557] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)