Difference between revisions of "UvrA"

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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yvzB]]'', ''[[uvrB]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yvzB]]'', ''[[uvrB]]''
 
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35160 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35160 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35160 Advanced_DNA]
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35160 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35160 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35160 DNA_with_flanks]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:uvrA_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:uvrA_context.gif]]

Revision as of 11:23, 14 May 2013

  • Description: excinuclease ABC (subunit A)

Gene name uvrA
Synonyms
Essential no
Product excinuclease ABC (subunit A)
Function DNA repair after UV damage
Gene expression levels in SubtiExpress: uvrA
Interactions involving this protein in SubtInteract: UvrA
MW, pI 105 kDa, 5.843
Gene length, protein length 2871 bp, 957 aa
Immediate neighbours yvzB, uvrB
Sequences Protein DNA DNA_with_flanks
Genetic context
UvrA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
UvrA expression.png
























Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

LexA regulon

The gene

Basic information

  • Locus tag: BSU35160

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: UvrA subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2R6F (Geobacillus stearothermophilus)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • mutant: GP1175 (del uvrAB::ermC) (available in the Stülke lab)
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original Publications

Bradley T Smith, Alan D Grossman, Graham C Walker
Localization of UvrA and effect of DNA damage on the chromosome of Bacillus subtilis.
J Bacteriol: 2002, 184(2);488-93
[PubMed:11751826] [WorldCat.org] [DOI] (P p)

C M Lovett, K C Cho, T M O'Gara
Purification of an SOS repressor from Bacillus subtilis.
J Bacteriol: 1993, 175(21);6842-9
[PubMed:8226626] [WorldCat.org] [DOI] (P p)