YjmD

• Description: galactitol-1-phosphate dehydrogenase
  
  

Gene name	yjmD
Synonyms
Essential	no
Product	galactitol-1-phosphate dehydrogenase
Function	utilization of dulcitol
Gene expression levels in SubtiExpress: yjmD
MW, pI	36 kDa, 6.115
Gene length, protein length	1017 bp, 339 aa
Immediate neighbours	yjmC, uxuA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources, sporulation proteins

This gene is a member of the following regulons

CcpA regulon, ExuR regulon, SigE regulon

The gene

Basic information

• Locus tag: BSU12330

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: zinc-containing alcohol dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O35045

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA PubMed
  • yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA PubMed

• Expression browser: yjmD PubMed

• Sigma factor: SigE PubMed
  • uxaC: SigA PubMed
  • yjmC: SigE PubMed

• Regulation:
  • repressed by glucose (CcpA) PubMed1 PubMed2
  • induced by galacturonate (ExuR) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed1 PubMed2
  • ExuR: reanscription repression in the absence of inducer PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Bogumiła C Marciniak, Monika Pabijaniak, Anne de Jong, Robert Dűhring, Gerald Seidel, Wolfgang Hillen, Oscar P Kuipers
High- and low-affinity cre boxes for CcpA binding in Bacillus subtilis revealed by genome-wide analysis.
BMC Genomics: 2012, 13;401
[PubMed:22900538] [WorldCat.org] [DOI] (I e)

You-Kwan Oh, Bernhard O Palsson, Sung M Park, Christophe H Schilling, Radhakrishnan Mahadevan
Genome-scale reconstruction of metabolic network in Bacillus subtilis based on high-throughput phenotyping and gene essentiality data.
J Biol Chem: 2007, 282(39);28791-28799
[PubMed:17573341] [WorldCat.org] [DOI] (P p)

Y Miwa, A Nakata, A Ogiwara, M Yamamoto, Y Fujita
Evaluation and characterization of catabolite-responsive elements (cre) of Bacillus subtilis.
Nucleic Acids Res: 2000, 28(5);1206-10
[PubMed:10666464] [WorldCat.org] [DOI] (I p)

K R Mekjian, E M Bryan, B W Beall, C P Moran
Regulation of hexuronate utilization in Bacillus subtilis.
J Bacteriol: 1999, 181(2);426-33
[PubMed:9882655] [WorldCat.org] [DOI] (P p)

Carlo Rivolta, Blazenka Soldo, Vladimir Lazarevic, Bernard Joris, Catherine Mauël, Dimitri Karamat
A 35.7 kb DNA fragment from the Bacillus subtilis chromosome containing a putative 12.3 kb operon involved in hexuronate catabolism and a perfectly symmetrical hypothetical catabolite-responsive element.
Microbiology (Reading): 1998, 144 ( Pt 4);877-884
[PubMed:9579062] [WorldCat.org] [DOI] (P p)