Difference between revisions of "MutM"

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* '''Description:''' formamidopyrimidine-DNA glycosidase <br/><br/>
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{| align="right" border="1" cellpadding="2"
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|-
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|style="background:#ABCDEF;" align="center"|'''Gene name'''
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|''mutM''
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|-
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|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ytaE ''
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|-
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no
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|-
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|style="background:#ABCDEF;" align="center"| '''Product''' || formamidopyrimidine-DNA glycosidase
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|-
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|style="background:#ABCDEF;" align="center"|'''Function''' || DNA repair
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|-
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU29080 mutM]
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|-
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 31 kDa, 8.889 
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|-
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|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 834 bp, 278 aa
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|-
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ytaF]]'', ''[[polA]]''
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|-
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU29080 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU29080 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU29080 Advanced_DNA]
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|-
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|colspan="2" | '''Genetic context''' <br/> [[Image:mutM_context.gif]]
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<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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|-
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|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mutM_2972329_2973159_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:mutM_expression.png|500px]]
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|-
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|}
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__TOC__
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<br/><br/><br/><br/>
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<br/><br/><br/><br/>
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<br/><br/><br/><br/>
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<br/><br/><br/><br/>
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<br/><br/><br/><br/>
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<br/><br/>
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= [[Categories]] containing this gene/protein =
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{{SubtiWiki category|[[DNA repair/ recombination]]}}
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= This gene is a member of the following [[regulons]] =
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=The gene=
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=== Basic information ===
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* '''Locus tag:''' BSU29080
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===Phenotypes of a mutant ===
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=== Database entries ===
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* '''DBTBS entry:''' no entry
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* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12628]
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=== Additional information===
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=The protein=
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=== Basic information/ Evolution ===
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* '''Catalyzed reaction/ biological activity:''' Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine (according to Swiss-Prot)
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* '''Protein family:''' FPG family (according to Swiss-Prot)
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* '''Paralogous protein(s):'''
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=== Extended information on the protein ===
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* '''Kinetic information:'''
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* '''Domains:'''
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* '''Modification:'''
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* '''Cofactor(s):'''
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* '''Effectors of protein activity:'''
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* '''[[SubtInteract|Interactions]]:'''
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* '''[[Localization]]:'''
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** cytoplasm (according to Swiss-Prot)
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=== Database entries ===
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* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2F5S 2F5S] (complex with oxoG:C, Geobacillus stearothermophilus)
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* '''UniProt:''' [http://www.uniprot.org/uniprot/O34403 O34403]
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* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU29080]
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* '''E.C. number:''' [http://www.expasy.org/enzyme/3.2.2.23 3.2.2.23]
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=== Additional information===
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=Expression and regulation=
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* '''Operon:'''
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mutM_2972329_2973159_-1 mutM] {{PubMed|22383849}}
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* '''Sigma factor:'''
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* '''Regulation:'''
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* '''Regulatory mechanism:'''
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* '''Additional information:'''
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=Biological materials =
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* '''Mutant:'''
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* '''Expression vector:'''
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* '''lacZ fusion:'''
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* '''GFP fusion:'''
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* '''two-hybrid system:'''
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* '''Antibody:'''
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=Labs working on this gene/protein=
 +
 
 +
=Your additional remarks=
 +
 
 +
=References=
 +
<pubmed> 19011023 19889642 </pubmed>
 +
[[Category:Protein-coding genes]]

Revision as of 19:31, 13 May 2013

  • Description: formamidopyrimidine-DNA glycosidase

Gene name mutM
Synonyms ytaE
Essential no
Product formamidopyrimidine-DNA glycosidase
Function DNA repair
Gene expression levels in SubtiExpress: mutM
MW, pI 31 kDa, 8.889
Gene length, protein length 834 bp, 278 aa
Immediate neighbours ytaF, polA
Sequences Protein DNA Advanced_DNA
Genetic context
MutM context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MutM expression.png
























Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU29080

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine (according to Swiss-Prot)
  • Protein family: FPG family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2F5S (complex with oxoG:C, Geobacillus stearothermophilus)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

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