Difference between revisions of "MutTA"
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|style="background:#ABCDEF;" align="center"|'''Function''' || DNA repair, RNA degradation | |style="background:#ABCDEF;" align="center"|'''Function''' || DNA repair, RNA degradation | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU30630 mutTA] |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 18 kDa, 5.952 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 18 kDa, 5.952 | ||
| Line 22: | Line 22: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ytlD]]'', ''[[ytkC]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ytlD]]'', ''[[ytkC]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU30630 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU30630 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU30630 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:ytkD_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:ytkD_context.gif]] | ||
Revision as of 13:40, 13 May 2013
- Description: error prevention oxidized guanine system, confers protection against oxidative stress to vegetative cells, moreover the protein has RNA pyrophosphohydrolase activity
| Gene name | mutTA |
| Synonyms | ytkD, rppH |
| Essential | no |
| Product | 8-oxo-dGTPase (antimutator), RNA pyrophosphohydrolase |
| Function | DNA repair, RNA degradation |
| Gene expression levels in SubtiExpress: mutTA | |
| MW, pI | 18 kDa, 5.952 |
| Gene length, protein length | 474 bp, 158 aa |
| Immediate neighbours | ytlD, ytkC |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
DNA repair/ recombination, sporulation proteins, RNases
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU30630
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- removal of pyrophosphate from the 5' end of mRNAs to make the RNA accessible for degradation by RNases PubMed
- RppH requires at least two unpaired nucleotides at the 5' end of its RNA substrates and prefers three or more. The second of these 5'-terminal nucleotides must be G, whereas a less strict preference for a purine is evident at the third position, and A is slightly favored over G at the first position PubMed
- Protein family: Nudix hydrolase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- UniProt: O35013
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Martin Lehnik-Habrink, Richard J Lewis, Ulrike Mäder, Jörg Stülke
RNA degradation in Bacillus subtilis: an interplay of essential endo- and exoribonucleases.
Mol Microbiol: 2012, 84(6);1005-17
[PubMed:22568516]
[WorldCat.org]
[DOI]
(I p)
Original publications
