Difference between revisions of "CcdA"
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|style="background:#ABCDEF;" align="center"|'''Function''' || cytochrome c synthesis | |style="background:#ABCDEF;" align="center"|'''Function''' || cytochrome c synthesis | ||
|- | |- | ||
| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU17930 ccdA] |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 25 kDa, 9.667 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 25 kDa, 9.667 | ||
| Line 22: | Line 22: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ynzD]]'', ''[[yneI]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ynzD]]'', ''[[yneI]]'' | ||
|- | |- | ||
| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU17930 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU17930 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU17930 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:ccdA_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:ccdA_context.gif]] | ||
Revision as of 12:56, 13 May 2013
- Description: membrane-embedded thiol-disulfide oxidoreductase
| Gene name | ccdA |
| Synonyms | |
| Essential | no |
| Product | thiol-disulfide oxidoreductase |
| Function | cytochrome c synthesis |
| Gene expression levels in SubtiExpress: ccdA | |
| MW, pI | 25 kDa, 9.667 |
| Gene length, protein length | 705 bp, 235 aa |
| Immediate neighbours | ynzD, yneI |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
respiration, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU17930
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: dsbD family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P45706
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Lýdur S Erlendsson, Lars Hederstedt
Mutations in the thiol-disulfide oxidoreductases BdbC and BdbD can suppress cytochrome c deficiency of CcdA-defective Bacillus subtilis cells.
J Bacteriol: 2002, 184(5);1423-9
[PubMed:11844773]
[WorldCat.org]
[DOI]
(P p)
N E Le Brun, J Bengtsson, L Hederstedt
Genes required for cytochrome c synthesis in Bacillus subtilis.
Mol Microbiol: 2000, 36(3);638-50
[PubMed:10844653]
[WorldCat.org]
[DOI]
(P p)
T Schiött, L Hederstedt
Efficient spore synthesis in Bacillus subtilis depends on the CcdA protein.
J Bacteriol: 2000, 182(10);2845-54
[PubMed:10781554]
[WorldCat.org]
[DOI]
(P p)
T Schiött, M Throne-Holst, L Hederstedt
Bacillus subtilis CcdA-defective mutants are blocked in a late step of cytochrome c biogenesis.
J Bacteriol: 1997, 179(14);4523-9
[PubMed:9226261]
[WorldCat.org]
[DOI]
(P p)
T Schiött, C von Wachenfeldt, L Hederstedt
Identification and characterization of the ccdA gene, required for cytochrome c synthesis in Bacillus subtilis.
J Bacteriol: 1997, 179(6);1962-73
[PubMed:9068642]
[WorldCat.org]
[DOI]
(P p)
