Difference between revisions of "ProG"
| Line 13: | Line 13: | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of proline | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of proline | ||
|- | |- | ||
| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU12910 proG] |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/proline.html Pro], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/proline.html Pro], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]''' | ||
| Line 23: | Line 23: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[htrA]]'', ''[[dppA]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[htrA]]'', ''[[dppA]]'' | ||
|- | |- | ||
| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU12910 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU12910 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU12910 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:proG_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:proG_context.gif]] | ||
Revision as of 12:37, 13 May 2013
- Description: 1-pyrroline-5-carboxylate dehydrogenase, the precise role of ProG is unknown
| Gene name | proG |
| Synonyms | ykeA, yzcA |
| Essential | no |
| Product | 1-pyrroline-5-carboxylate dehydrogenase |
| Function | biosynthesis of proline |
| Gene expression levels in SubtiExpress: proG | |
| Metabolic function and regulation of this protein in SubtiPathways: Pro, Stress | |
| MW, pI | 30 kDa, 4.914 |
| Gene length, protein length | 816 bp, 272 aa |
| Immediate neighbours | htrA, dppA |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU12910
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H (according to Swiss-Prot)
- Protein family: pyrroline-5-carboxylate reductase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: Q00777
- KEGG entry: [3]
- E.C. number: 1.5.1.2
Additional information
Expression and regulation
- Operon: proG PubMed
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
B R Belitsky, J Brill, E Bremer, A L Sonenshein
Multiple genes for the last step of proline biosynthesis in Bacillus subtilis.
J Bacteriol: 2001, 183(14);4389-92
[PubMed:11418582]
[WorldCat.org]
[DOI]
(P p)
C Mathiopoulos, J P Mueller, F J Slack, C G Murphy, S Patankar, G Bukusoglu, A L Sonenshein
A Bacillus subtilis dipeptide transport system expressed early during sporulation.
Mol Microbiol: 1991, 5(8);1903-13
[PubMed:1766370]
[WorldCat.org]
[DOI]
(P p)
