Difference between revisions of "RsbT"

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* '''Description:''' PP2C activator, [[protein kinases and phosphatases|protein serine kinase]], phosphorylates [[RsbS]] and [[RsbR]], part of the [[stressosome]] <br/><br/>
 
 
 
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= [[Categories]] containing this gene/protein =
 
= [[Categories]] containing this gene/protein =
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=== Additional information===
 
=== Additional information===
 
 
  
  
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* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
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** phosphorylated [[RsbR]] activates the kinase activity of [[RsbT]] {{PubMed|23320651}}
  
 
* '''[[SubtInteract|Interactions]]:'''
 
* '''[[SubtInteract|Interactions]]:'''
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==Original Articles==
 
==Original Articles==
'''Additional publications:''' {{PubMed|21362065}}
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'''Additional publications:''' {{PubMed|23320651,21362065}}
 
  <big>''Locke JC, Young JW, Fontes M, Hernández Jiménez MJ, Elowitz MB''  </big>
 
  <big>''Locke JC, Young JW, Fontes M, Hernández Jiménez MJ, Elowitz MB''  </big>
 
  <big>'''Stochastic pulse regulation in bacterial stress response.''' </big>
 
  <big>'''Stochastic pulse regulation in bacterial stress response.''' </big>

Revision as of 12:29, 5 February 2013

Gene name rsbT
Synonyms ycxT
Essential no
Product PP2C activator, protein serine kinase
Function control of SigB activity
Gene expression levels in SubtiExpress: rsbT
Interactions involving this protein in SubtInteract: RsbT
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 14 kDa, 6.587
Gene length, protein length 399 bp, 133 aa
Immediate neighbours rsbS, rsbU
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
RsbT context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
RsbT expression.png















Categories containing this gene/protein

protein modification, sigma factors and their control

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU04690

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 3VY9 (complete stressosome)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: constitutively expressed PubMed
  • Regulatory mechanism:
  • Additional information:
    • RsbT is synthesized at the same rate as RsbRA and RsbS, however, the RsbT level in growing B. subtilis is only 10% that of RsbRA, suggesting that the protein is unstable PubMed.

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews


Original Articles

Additional publications: PubMed

Locke JC, Young JW, Fontes M, Hernández Jiménez MJ, Elowitz MB  
Stochastic pulse regulation in bacterial stress response. 
Science. 2011 334:366-369. 
PubMed:21979936