Difference between revisions of "HprT"

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[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 12:21, 21 September 2012

  • Description: hypoxanthine phosphoribosyltransferase

Gene name hprT
Synonyms
Essential yes PubMed
Product hypoxanthine phosphoribosyltransferase
Function purine salvage and interconversion
Gene expression levels in SubtiExpress: hprT
Metabolic function and regulation of this protein in SubtiPathways:
Purine salvage, Purine synthesis, Nucleotides (regulation)
MW, pI 20 kDa, 4.603
Gene length, protein length 540 bp, 180 aa
Immediate neighbours tilS, ftsH
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HprT context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HprT expression.png



















Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes

This gene is a member of the following regulons

SigM regulon

The gene

Basic information

  • Locus tag: BSU00680

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
  • Protein family: purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
    • inhibition of enzymatic activity by (p)ppGpp during the ´stringent response´PubMed

Database entries

  • Structure: 1J7J (from Salmonella typhimurium, 51% identity, 73% similarity)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References