Ung

• Description: uracil-DNA glycosylase
  
  

Gene name	ung
Synonyms	ipa-57d, ywdG
Essential	no
Product	uracil-DNA glycosylase
Function	DNA repair
Gene expression levels in SubtiExpress: ung
Interactions involving this protein in SubtInteract: Ung
MW, pI	25 kDa, 8.782
Gene length, protein length	675 bp, 225 aa
Immediate neighbours	ywdH, ywdF
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination

The gene

Basic information

• Locus tag: BSU37970

Phenotypes of a mutant

• increased mutation rates PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: removes uracil preferentially from single-stranded DNA over double-stranded DNA, exhibiting higher preference for U:G than U:A mismatches PubMed

• Protein family: uracil-DNA glycosylase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • SsbA-Ung PubMed

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 3A7N (from Mycobacterium tuberculosis, 42% identity) PubMed

• UniProt: P39615

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ung PubMed

• Expression browser: ung PubMed

• Sigma factor:

• Regulation:
  • expressed throughout growth and staionary phase PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed