Difference between revisions of "MutTA"

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|style="background:#ABCDEF;" align="center"|'''Function''' || DNA repair, RNA degradation
 
|style="background:#ABCDEF;" align="center"|'''Function''' || DNA repair, RNA degradation
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU30630 mutTA]
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 18 kDa, 5.952   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 18 kDa, 5.952   

Revision as of 15:13, 7 August 2012

  • Description: error prevention oxidized guanine system, confers protection against oxidative stress to vegetative cells, moreover the protein has RNA pyrophosphohydrolase activity

Gene name mutTA
Synonyms ytkD, rppH
Essential no
Product 8-oxo-dGTPase (antimutator), RNA pyrophosphohydrolase
Function DNA repair, RNA degradation
Gene expression levels in SubtiExpress: mutTA
MW, pI 18 kDa, 5.952
Gene length, protein length 474 bp, 158 aa
Immediate neighbours ytlD, ytkC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YtkD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MutTA expression.png
























Categories containing this gene/protein

DNA repair/ recombination, sporulation proteins, RNases

This gene is a member of the following regulons

SigF regulon

The gene

Basic information

  • Locus tag: BSU30630

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • removal of pyrophosphate from the 5' end of mRNAs to make the RNA accessible for degradation by RNases PubMed
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed during logarithmic growth (SigA) and early during sporulation in the forespore (SigF) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Lehnik-Habrink M, Lewis RJ, Mäder U, Stülke J    
RNA degradation in Bacillus subtilis: an interplay of
essential endo- and exoribonucleases. 
Mol Microbiol.: 2012, 84(6) 1005-1017. 
PubMed:22568516

Original publications