Difference between revisions of "AdaA"

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* '''Description:''' [[trigger enzymes|trigger enzyme]]: methylphosphotriester-DNA alkyltransferase/ transcriptional activator of the ''[[adaA]]-[[adaB]]'' operon <br/><br/>
  
 
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|style="background:#ABCDEF;" align="center"|'''Function''' || adaptive response to alkylative DNA damage
 
|style="background:#ABCDEF;" align="center"|'''Function''' || adaptive response to alkylative DNA damage
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU01810 adaA]
 
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 24 kDa, 9.185   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 24 kDa, 9.185   
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|colspan="2" | '''Genetic context''' <br/> [[Image:adaA_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:adaA_context.gif]]
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=adaA_203729_204364_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:adaA_expression.png|500px]]
 
 
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* '''Operon:''' ''[[adaA]]-[[adaB]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed]
 
* '''Operon:''' ''[[adaA]]-[[adaB]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed]
  
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=adaA_203729_204364_1 adaA] {{PubMed|22383849}}
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* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed]
 
 
* '''Sigma factor:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed]
 
  
 
* '''Regulation:''' positive control by [[AdaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed]
 
* '''Regulation:''' positive control by [[AdaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed]

Revision as of 10:42, 7 August 2012

  • Description: trigger enzyme: methylphosphotriester-DNA alkyltransferase/ transcriptional activator of the adaA-adaB operon

Gene name adaA
Synonyms
Essential no
Product trigger enzyme: methylphosphotriester-DNA alkyltransferase/
transcriptional activator of the adaAB operon
Function adaptive response to alkylative DNA damage
MW, pI 24 kDa, 9.185
Gene length, protein length 633 bp, 211 aa
Immediate neighbours alkA, adaB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
AdaA context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

DNA repair/ recombination, transcription factors and their control, trigger enzyme

This gene is a member of the following regulons

AdaA regulon

The gene

Basic information

  • Locus tag: BSU01810

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

F Morohoshi, K Hayashi, N Munkata
Bacillus subtilis alkA gene encoding inducible 3-methyladenine DNA glycosylase is adjacent to the ada operon.
J Bacteriol: 1993, 175(18);6010-7
[PubMed:8376346] [WorldCat.org] [DOI] (P p)

F Morohoshi, K Hayashi, N Munakata
Bacillus subtilis ada operon encodes two DNA alkyltransferases.
Nucleic Acids Res: 1990, 18(18);5473-80
[PubMed:2120677] [WorldCat.org] [DOI] (P p)