Difference between revisions of "IspD"

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* '''Description:''' 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase <br/><br/>
  
 
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|style="background:#ABCDEF;" align="center"|'''Function''' || isoprenoid biosynthesis
 
|style="background:#ABCDEF;" align="center"|'''Function''' || isoprenoid biosynthesis
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU00900 ispD]
 
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 25 kDa, 5.579   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 25 kDa, 5.579   
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|colspan="2" | '''Genetic context''' <br/> [[Image:yacM_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:yacM_context.gif]]
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ispD_109789_110487_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:ispD_expression.png|500px]]
 
 
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* '''Operon:''' ''[[yacL]]-[[ispD]]-[[ispF]]'' {{PubMed|10482513}}
 
* '''Operon:''' ''[[yacL]]-[[ispD]]-[[ispF]]'' {{PubMed|10482513}}
  
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ispD_109789_110487_1 ispD] {{PubMed|22383849}}
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* '''[[Sigma factor]]:''' [[SigB]] [http://www.ncbi.nlm.nih.gov/pubmed/15805528 PubMed], [[SigM]] [http://www.ncbi.nlm.nih.gov/sites/entrez/17434969 PubMed]
 
 
* '''Sigma factor:''' [[SigB]] [http://www.ncbi.nlm.nih.gov/pubmed/15805528 PubMed], [[SigM]] [http://www.ncbi.nlm.nih.gov/sites/entrez/17434969 PubMed]
 
  
 
* '''Regulation:'''  induced by stress ([[SigB]]) [http://www.ncbi.nlm.nih.gov/pubmed/15805528 PubMed]
 
* '''Regulation:'''  induced by stress ([[SigB]]) [http://www.ncbi.nlm.nih.gov/pubmed/15805528 PubMed]

Revision as of 10:25, 7 August 2012

  • Description: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Gene name ispD
Synonyms yacM
Essential yes PubMed
Product 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Function isoprenoid biosynthesis
MW, pI 25 kDa, 5.579
Gene length, protein length 696 bp, 232 aa
Immediate neighbours yacL, ispF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YacM context.gif
This image was kindly provided by SubtiList




Categories containing this gene/protein

biosynthesis of lipids, general stress proteins (controlled by SigB), cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes

This gene is a member of the following regulons

SigB regulon, SigM regulon

The gene

Basic information

  • Locus tag: BSU00900

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol (according to Swiss-Prot)
  • Protein family: ispD family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References