AprX

• Description: intracellular alkaline serine protease
  
  

Gene name	aprX
Synonyms
Essential	no
Product	intracellular alkaline serine protease
Function	protein degradation
Gene expression levels in SubtiExpress: aprX
MW, pI	47 kDa, 4.974
Gene length, protein length	1326 bp, 442 aa
Immediate neighbours	ymaE, ymaC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of nitrogen sources other than amino acids

This gene is a member of the following regulons

LexA regulon

The gene

Basic information

• Locus tag: BSU17260

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O31788

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: aprX (according to [DBTBS])

• Expression browser: aprX PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by DNA damage (LexA) PubMed

• Regulatory mechanism:
  • LexA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Alessandra Albertini, University of Pavia, Italy homepage

References

Nora Au, Elke Kuester-Schoeck, Veena Mandava, Laura E Bothwell, Susan P Canny, Karen Chachu, Sierra A Colavito, Shakierah N Fuller, Eli S Groban, Laura A Hensley, Theresa C O'Brien, Amish Shah, Jessica T Tierney, Louise L Tomm, Thomas M O'Gara, Alexi I Goranov, Alan D Grossman, Charles M Lovett
Genetic composition of the Bacillus subtilis SOS system.
J Bacteriol: 2005, 187(22);7655-66
[PubMed:16267290] [WorldCat.org] [DOI] (P p)

Angela Valbuzzi, Eugenio Ferrari, Alessandra M Albertini
A novel member of the subtilisin-like protease family from Bacillus subtilis.
Microbiology (Reading): 1999, 145 ( Pt 11);3121-3127
[PubMed:10589719] [WorldCat.org] [DOI] (P p)