Difference between revisions of "GutR"

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* '''Description:''' transcription activator of the ''[[gutB]]-[[gutP]]'' operon <br/><br/>
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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of glucitol utilization
 
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of glucitol utilization
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU06140 gutR]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]'''

Revision as of 15:35, 6 August 2012


Gene name gutR
Synonyms
Essential no
Product transcription activator
Function regulation of glucitol utilization
Gene expression levels in SubtiExpress: gutR
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 94 kDa, 6.113
Gene length, protein length 2487 bp, 829 aa
Immediate neighbours ydjC, gutB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
GutR context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GutR expression.png




























Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control

This gene is a member of the following regulons

The GutR regulon:

The gene

Basic information

  • Locus tag: BSU06140

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Shouji Watanabe, Miyuki Hamano, Hiroshi Kakeshita, Keigo Bunai, Shigeo Tojo, Hirotake Yamaguchi, Yasutaro Fujita, Sui-Lam Wong, Kunio Yamane
Mannitol-1-phosphate dehydrogenase (MtlD) is required for mannitol and glucitol assimilation in Bacillus subtilis: possible cooperation of mtl and gut operons.
J Bacteriol: 2003, 185(16);4816-24
[PubMed:12897001] [WorldCat.org] [DOI] (P p)

K K Poon, J C Chu, S L Wong
Roles of glucitol in the GutR-mediated transcription activation process in Bacillus subtilis: glucitol induces GutR to change its conformation and to bind ATP.
J Biol Chem: 2001, 276(32);29819-25
[PubMed:11390381] [WorldCat.org] [DOI] (P p)

K K Poon, C L Chen, S L Wong
Roles of glucitol in the GutR-mediated transcription activation process in Bacillus subtilis: tight binding of GutR to tis binding site.
J Biol Chem: 2001, 276(13);9620-5
[PubMed:11118449] [WorldCat.org] [DOI] (P p)

R Ye, S N Rehemtulla, S L Wong
Glucitol induction in Bacillus subtilis is mediated by a regulatory factor, GutR.
J Bacteriol: 1994, 176(11);3321-7
[PubMed:8195087] [WorldCat.org] [DOI] (P p)

R Ye, S L Wong
Transcriptional regulation of the Bacillus subtilis glucitol dehydrogenase gene.
J Bacteriol: 1994, 176(11);3314-20
[PubMed:8195086] [WorldCat.org] [DOI] (P p)