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<big>'''Paper of the month: January 2012'''</big> | <big>'''Paper of the month: January 2012'''</big> | ||
| − | * [http://www.ncbi.nlm.nih.gov/pubmed/ | + | * [http://www.ncbi.nlm.nih.gov/pubmed/22303282 Levine ''et al''.] from the lab of [[Michael Elowitz]] show how ''B. subtilis'' cells can defer [[sporulation proteins|sporulation]] for multiple cell cycles in response to sudden environmental stress. This deferral is controlled by a pulsed positive feedback loop in which [[phosphorelay]] kinase expression is activated by pulses of [[Spo0A]] phosphorylation. |
| − | * '''Relevant ''Subti''Wiki pages:''' [[ | + | * '''Relevant ''Subti''Wiki pages:''' [[Michael Elowitz]], [[Jonathan Dworkin]], [[phosphorelay], [[sporulation proteins|sporulation]], [[Spo0A]] |
| − | <pubmed> | + | <pubmed> 22303282 </pubmed> |
| + | * '''A comment on this paper:''' | ||
| + | <pubmed> 22303284 </pubmed> | ||
| + | |||
* [[Previous papers of the month]] | * [[Previous papers of the month]] | ||
Revision as of 16:53, 9 February 2012
Welcome to SubtiWiki! - Bacillus subtilis annotation the "wiki" way!
Contact: General Microbiology, University of Göttingen, send mail
Upcoming events:
- April 16 - 19, 2012: The 5th European Spore Conference will take place in London, UK. contact, conference website
- April 24 - 25, 2012: The BACELL meeting 2012 will be organized by Kevin Devine in Dublin, Ireland. contact
New: Subtiwiki is now on Facebook - please give it a +1!
Now online: A description of SubtiWiki, SubtiPathways, and SubtInteract in the 2012 Database issue of Nucleic Acids Research
Paper of the month: January 2012
- Levine et al. from the lab of Michael Elowitz show how B. subtilis cells can defer sporulation for multiple cell cycles in response to sudden environmental stress. This deferral is controlled by a pulsed positive feedback loop in which phosphorelay kinase expression is activated by pulses of Spo0A phosphorylation.
- Relevant SubtiWiki pages: Michael Elowitz, Jonathan Dworkin, [[phosphorelay], sporulation, Spo0A
Joe H Levine, Michelle E Fontes, Jonathan Dworkin, Michael B Elowitz
Pulsed feedback defers cellular differentiation.
PLoS Biol: 2012, 10(1);e1001252
[PubMed:22303282]
[WorldCat.org]
[DOI]
(I p)
- A comment on this paper:
Liza Gross
Built-in timer delays differentiation.
PLoS Biol: 2012, 10(1);e1001254
[PubMed:22303284]
[WorldCat.org]
[DOI]
(I p)
New procedure for account creation:
- Due to massive spam attacks, we had to change our policy for the creation of accounts. If you want to create an account, just send me a mail. We will create the account for you as quickly as possible, then you can change your password. This does not affect existing accounts, which remain active.
- Please remember that all members of the Bacillus community are invited to create accounts and to contribute to SubtiWiki!
News in SubtiWiki:
- June 2011: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
- April 2011: SubtInteract, a presentation of protein-protein interactions in B. subtilis, is online!
- December 2010: SubtiCellPublisher allows the conversion of CellDesigner diagrams to navigatable presentations in the style of SubtiPathways
- December 2010: all genes are linked to regulons, and the pages of the regulons provide an overview on all genes that are members of this specific regulon.
- December 2010: all genes/proteins are linked to categories, and the pages of the categories provide an overview on all genes/proteins that are members of this specific category.
- August 2010: several new pathway maps including Utilization of other nitrogen sources, Biotin synthesis, Murein recycling, and Protein secretion were uploaded to SubtiPathways
- March 2010: novel plasmids for the creation of strains expressing proteins with a C-terminal triple FLAG-tag (for simple immunological analysis of the proteins, pGP1087 and pGP1331)
Publications describing SubtiWiki and SubtiPathways:
Lope A Flórez, Sebastian F Roppel, Arne G Schmeisky, Christoph R Lammers, Jörg Stülke
A community-curated consensual annotation that is continuously updated: the Bacillus subtilis centred wiki SubtiWiki.
Database (Oxford): 2009, 2009;bap012
[PubMed:20157485]
[WorldCat.org]
[DOI]
(I p)
Christoph R Lammers, Lope A Flórez, Arne G Schmeisky, Sebastian F Roppel, Ulrike Mäder, Leendert Hamoen, Jörg Stülke
Connecting parts with processes: SubtiWiki and SubtiPathways integrate gene and pathway annotation for Bacillus subtilis.
Microbiology (Reading): 2010, 156(Pt 3);849-859
[PubMed:19959575]
[WorldCat.org]
[DOI]
(I p)
