YclP

• Description: petrobactin (3.4-catecholate siderophore) ABC transporter (ATP-binding protein)
  
  

Gene name	yclP
Synonyms
Essential	no
Product	petrobactin ABC transporter (ATP-binding protein)
Function	acquisition of iron
Interactions involving this protein in SubtInteract: YclP
MW, pI	28 kDa, 5.085
Gene length, protein length	756 bp, 252 aa
Immediate neighbours	yclO, yclQ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

ABC transporters, acquisition of iron, iron metabolism, membrane proteins

This gene is a member of the following regulons

Fur regulon

The gene

Basic information

• Locus tag: BSU03820

Expression

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: uptake of the siderophore petrobactin PubMed

• Protein family: ABC transporter domain (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: YclP-(YclN-YclO)-YclQ PubMed

• Localization: associated to the membrane (via YclN-YclO) PubMed

Database entries

• Structure:

• UniProt: P94420

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: yclN-yclO-yclP-yclQ PubMed

• Sigma factor:

• Regulation:
  • repressed unless the cells enter an iron starvation (Fur) PubMed

• Regulatory mechanism:
  • Fur: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Anna M Zawadzka, Youngchang Kim, Natalia Maltseva, Rita Nichiporuk, Yao Fan, Andrzej Joachimiak, Kenneth N Raymond
Characterization of a Bacillus subtilis transporter for petrobactin, an anthrax stealth siderophore.
Proc Natl Acad Sci U S A: 2009, 106(51);21854-9
[PubMed:19955416] [WorldCat.org] [DOI] (I p)

Noel Baichoo, Tao Wang, Rick Ye, John D Helmann
Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon.
Mol Microbiol: 2002, 45(6);1613-29
[PubMed:12354229] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)