ZnuA

• Description: ABC transporter for zinc (binding protein)
  
  

Gene name	znuA
Synonyms	ycdH
Essential	no
Product	ABC transporter for zinc (binding protein)
Function	zinc uptake
Interactions involving this protein in SubtInteract: ZnuA
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	35 kDa, 5.146
Gene length, protein length	957 bp, 319 aa
Immediate neighbours	ycdG, znuC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

ABC transporters, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), membrane proteins

This gene is a member of the following regulons

Zur regulon

The gene

Basic information

• Locus tag: BSU02850

Expression

Phenotypes of a mutant

• • reduced genetic competence, can be rescued by the addition of excess zinc PubMed
  • reduced expression of the comFA-comFB-comFC-yvyF-flgM-yvyG-flgK-flgL operon PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: bacterial solute-binding protein 9 family (according to Swiss-Prot)

• Paralogous protein(s): MntA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: ZnuA-ZnuB-ZnuC PubMed

• Localization:
  • associated to the membrane (via ZnuB) PubMed
  • extracellular (signal peptide) PubMed

Database entries

• Structure: 2O1E

• UniProt: O34966

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: znuA-znuC-znuB PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by zinc starvation (Zur) PubMed

• Regulatory mechanism:
  • Zur: transcription repression in the presence of zinc PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: