Difference between revisions of "FtsH"
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=== Additional information=== | === Additional information=== | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' degrades [[Spo0E]], resulting in reduced sporulation frequency in a ''ftsH'' mutant | + | * '''Catalyzed reaction/ biological activity:''' degrades [[Spo0E]] and [[Spo0M]], resulting in reduced sporulation frequency in a ''ftsH'' mutant {{PubMed|22142536}} |
* '''Protein family:''' | * '''Protein family:''' | ||
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=References= | =References= | ||
| − | <pubmed>10913836,12533473,9076729,10851010,9084181,15386101,10077851,19332814,12884008,7608085,9352926,, 19332814, 18763711 12176385 18179421 </pubmed> | + | <pubmed>10913836,12533473,9076729,10851010,9084181,15386101,10077851,19332814,12884008,7608085,9352926,, 19332814, 18763711 12176385 18179421 22142536 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 12:29, 9 December 2011
- Description: ATP-dependent metalloprotease
| Gene name | ftsH |
| Synonyms | |
| Essential | no |
| Product | ATP-dependent metalloprotease |
| Function | cell division, sporulation initiation |
| Metabolic function and regulation of this protein in SubtiPathways: Phosphorelay, Stress | |
| MW, pI | 70 kDa, 5.841 |
| Gene length, protein length | 1911 bp, 637 aa |
| Immediate neighbours | hprT, coaX |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
cell division, cell envelope stress proteins (controlled by SigM, V, W, X, Y), heat shock proteins, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00690
Phenotypes of a mutant
strongly reduced sporulation frequency
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: degrades Spo0E and Spo0M, resulting in reduced sporulation frequency in a ftsH mutant PubMed
- Protein family:
- Paralogous protein(s): YjoB
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane PubMed
Database entries
- UniProt: P37476
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation: induced by heat shock (class III)
- Regulatory mechanism:
- Additional information: the mRNA is very stable (half-life > 15 min) PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
