Difference between revisions of "YtnP"
| Line 12: | Line 12: | ||
|style="background:#ABCDEF;" align="center"| '''Product''' || lactonase-homolog protein | |style="background:#ABCDEF;" align="center"| '''Product''' || lactonase-homolog protein | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || defense against competing bacteria |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.927 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.927 | ||
| Line 33: | Line 33: | ||
= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
{{SubtiWiki category|[[phosphoproteins]]}}, | {{SubtiWiki category|[[phosphoproteins]]}}, | ||
| − | {{SubtiWiki category|[[ | + | {{SubtiWiki category|[[resistance against toxins/ antibiotics]]}} |
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| Line 73: | Line 73: | ||
* '''Domains:''' | * '''Domains:''' | ||
| − | * '''Modification:''' phosphorylation on Ser- | + | * '''Modification:''' phosphorylation on Ser-36 [http://www.ncbi.nlm.nih.gov/sites/entrez/17218307 PubMed] |
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| Line 99: | Line 99: | ||
* '''Operon:''' | * '''Operon:''' | ||
| − | * ''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** induced in the presence of streptomycin {{PubMed|22101040}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
Revision as of 11:23, 22 November 2011
- Description: lactonase-homolog protein, inhibits the signalling pathway required for the streptomycin production and development of aerial mycelium in Streptomyces griseus
| Gene name | ytnP |
| Synonyms | |
| Essential | no |
| Product | lactonase-homolog protein |
| Function | defense against competing bacteria |
| MW, pI | 29 kDa, 5.927 |
| Gene length, protein length | 768 bp, 256 aa |
| Immediate neighbours | malS, trmB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
phosphoproteins, resistance against toxins/ antibiotics
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU29890
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylation on Ser-36 PubMed
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: O34760
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- induced in the presence of streptomycin PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Johannes Schneider, Ana Yepes, Juan C Garcia-Betancur, Isa Westedt, Benjamin Mielich, Daniel López
Streptomycin-induced expression in Bacillus subtilis of YtnP, a lactonase-homologous protein that inhibits development and streptomycin production in Streptomyces griseus.
Appl Environ Microbiol: 2012, 78(2);599-603
[PubMed:22101040]
[WorldCat.org]
[DOI]
(I p)
Boris Macek, Ivan Mijakovic, Jesper V Olsen, Florian Gnad, Chanchal Kumar, Peter R Jensen, Matthias Mann
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.
Mol Cell Proteomics: 2007, 6(4);697-707
[PubMed:17218307]
[WorldCat.org]
[DOI]
(P p)
