Difference between revisions of "TreR"
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* '''Regulation:''' | * '''Regulation:''' | ||
** induced by trehalose ([[TreR]]) {{PubMed|8755887}} | ** induced by trehalose ([[TreR]]) {{PubMed|8755887}} | ||
| − | ** repressed by glucose ([[CcpA]]) {{PubMed|18977770}} | + | ** repressed by glucose ([[CcpA]]) {{PubMed|18977770}} |
| + | ** expressed under conditions of phosphate limitation ([[PhoP]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/21636651 PubMed] | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
** [[TreR]]: transcription repression {{PubMed|8755887}} | ** [[TreR]]: transcription repression {{PubMed|8755887}} | ||
** [[CcpA]]: transcription repression {{PubMed|18977770}} | ** [[CcpA]]: transcription repression {{PubMed|18977770}} | ||
| + | ** [[PhoP]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/21636651 PubMed] | ||
* '''Additional information:''' | * '''Additional information:''' | ||
Revision as of 15:21, 19 October 2011
- Description: transcription repressor of the treP-treA-treR operon, (GntR family)
| Gene name | treR |
| Synonyms | yfxA |
| Essential | no |
| Product | transcription repressor, (GntR family) |
| Function | regulaation of trehalose utilization |
| Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism | |
| MW, pI | 27 kDa, 6.82 |
| Gene length, protein length | 714 bp, 238 aa |
| Immediate neighbours | treA, yfkO |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
utilization of specific carbon sources, transcription factors and their control
This gene is a member of the following regulons
CcpA regulon, PhoP regulon, TreR regulon
The TreR regulon
The gene
Basic information
- Locus tag: BSU07820
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- UniProt: P39796
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Hiromi Ujiie, Tomoko Matsutani, Hisashi Tomatsu, Ai Fujihara, Chisato Ushida, Yasuhiko Miwa, Yasutaro Fujita, Hyouta Himeno, Akira Muto
Trans-translation is involved in the CcpA-dependent tagging and degradation of TreP in Bacillus subtilis.
J Biochem: 2009, 145(1);59-66
[PubMed:18977770]
[WorldCat.org]
[DOI]
(I p)
Pavlína Rezácová, Veronika Krejciríková, Dominika Borek, Shiu F Moy, Andrzej Joachimiak, Zbyszek Otwinowski
The crystal structure of the effector-binding domain of the trehalose repressor TreR from Bacillus subtilis 168 reveals a unique quarternary assembly.
Proteins: 2007, 69(3);679-82
[PubMed:17705272]
[WorldCat.org]
[DOI]
(I p)
L Bürklen, F Schöck, M K Dahl
Molecular analysis of the interaction between the Bacillus subtilis trehalose repressor TreR and the tre operator.
Mol Gen Genet: 1998, 260(1);48-55
[PubMed:9829827]
[WorldCat.org]
[DOI]
(P p)
F Schöck, M K Dahl
Analysis of DNA flanking the treA gene of Bacillus subtilis reveals genes encoding a putative specific enzyme IITre and a potential regulator of the trehalose operon.
Gene: 1996, 175(1-2);59-63
[PubMed:8917076]
[WorldCat.org]
[DOI]
(P p)
F Schöck, M K Dahl
Expression of the tre operon of Bacillus subtilis 168 is regulated by the repressor TreR.
J Bacteriol: 1996, 178(15);4576-81
[PubMed:8755887]
[WorldCat.org]
[DOI]
(P p)
