Difference between revisions of "CsrA"
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| − | * '''Description:''' | + | * '''Description:''' motility regulator, binds to the ''[[hag]]'' mRNA to inhibit its translation <br/><br/> |
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
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| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || motility regulator |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || control of ''[[hag]]'' translation |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/CsrA CsrA] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/CsrA CsrA] | ||
| Line 34: | Line 34: | ||
= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
| − | {{SubtiWiki category|[[RNA binding regulators]]}} | + | {{SubtiWiki category|[[RNA binding regulators]]}}, |
| + | {{SubtiWiki category|[[motility and chemotaxis]]}} | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
Revision as of 17:01, 16 September 2011
- Description: motility regulator, binds to the hag mRNA to inhibit its translation
| Gene name | csrA |
| Synonyms | yviG |
| Essential | no |
| Product | motility regulator |
| Function | control of hag translation |
| Interactions involving this protein in SubtInteract: CsrA | |
| MW, pI | 8 kDa, 6.09 |
| Gene length, protein length | 222 bp, 74 aa |
| Immediate neighbours | hag, fliW |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
RNA binding regulators, motility and chemotaxis
This gene is a member of the following regulons
The CsrA regulon: hag
The gene
Basic information
- Locus tag: BSU35370
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Protein family: csrA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 1T3O
- UniProt: P33911
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: csrA PubMed
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant: GP469 (spc), available in Stülke lab
- Expression vector:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original Publications
Sampriti Mukherjee, Helen Yakhnin, Dave Kysela, Josh Sokoloski, Paul Babitzke, Daniel B Kearns
CsrA-FliW interaction governs flagellin homeostasis and a checkpoint on flagellar morphogenesis in Bacillus subtilis.
Mol Microbiol: 2011, 82(2);447-61
[PubMed:21895793]
[WorldCat.org]
[DOI]
(I p)
Helen Yakhnin, Pallavi Pandit, Tom J Petty, Carol S Baker, Tony Romeo, Paul Babitzke
CsrA of Bacillus subtilis regulates translation initiation of the gene encoding the flagellin protein (hag) by blocking ribosome binding.
Mol Microbiol: 2007, 64(6);1605-20
[PubMed:17555441]
[WorldCat.org]
[DOI]
(P p)
Prajna R Kulkarni, Xiaohui Cui, Joshua W Williams, Ann M Stevens, Rahul V Kulkarni
Prediction of CsrA-regulating small RNAs in bacteria and their experimental verification in Vibrio fischeri.
Nucleic Acids Res: 2006, 34(11);3361-9
[PubMed:16822857]
[WorldCat.org]
[DOI]
(I e)
B Soldo, V Lazarevic, C Mauël, D Karamata
Sequence of the 305 degrees-307 degrees region of the Bacillus subtilis chromosome.
Microbiology (Reading): 1996, 142 ( Pt 11);3079-88
[PubMed:8969505]
[WorldCat.org]
[DOI]
(P p)
