Difference between revisions of "HolA"
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|style="background:#ABCDEF;" align="center"| '''Product''' || DNA polymerase III, delta subunit | |style="background:#ABCDEF;" align="center"| '''Product''' || DNA polymerase III, delta subunit | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || DNA replication | + | |style="background:#ABCDEF;" align="center"|'''Function''' || [[DNA replication]] |
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/HolA HolA] | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 40 kDa, 6.231 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 40 kDa, 6.231 | ||
Revision as of 15:03, 29 July 2011
- Description: DNA polymerase III, delta subunit, part of the replisome
| Gene name | holA |
| Synonyms | yqeN |
| Essential | yes PubMed |
| Product | DNA polymerase III, delta subunit |
| Function | DNA replication |
| Interactions involving this protein in SubtInteract: HolA | |
| MW, pI | 40 kDa, 6.231 |
| Gene length, protein length | 1041 bp, 347 aa |
| Immediate neighbours | rpsT, comEC |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
DNA replication, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU25560
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions: part of the replisome: PolC-HolA-HolB-DnaX-DnaN-DnaG-DnaC-DnaI-DnaD-SsbA-DnaE-PriA-DnaB PubMed
- Localization: Nucleoid (Mid-cell) PubMed
Database entries
- Structure:
- UniProt: P54459
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Glenn M Sanders, H Garry Dallmann, Charles S McHenry
Reconstitution of the B. subtilis replisome with 13 proteins including two distinct replicases.
Mol Cell: 2010, 37(2);273-81
[PubMed:20122408]
[WorldCat.org]
[DOI]
(I p)
Jean-Christophe Meile, Ling Juan Wu, S Dusko Ehrlich, Jeff Errington, Philippe Noirot
Systematic localisation of proteins fused to the green fluorescent protein in Bacillus subtilis: identification of new proteins at the DNA replication factory.
Proteomics: 2006, 6(7);2135-46
[PubMed:16479537]
[WorldCat.org]
[DOI]
(P p)
