Difference between revisions of "PolC"
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|style="background:#ABCDEF;" align="center"| '''Product''' || DNA polymerase III (alpha subunit) | |style="background:#ABCDEF;" align="center"| '''Product''' || DNA polymerase III (alpha subunit) | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || DNA replication | + | |style="background:#ABCDEF;" align="center"|'''Function''' || [[DNA replication]] |
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/PolC PolC] | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 162 kDa, 5.135 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 162 kDa, 5.135 | ||
Revision as of 15:02, 29 July 2011
- Description: DNA polymerase III (alpha subunit), part of the replisome
| Gene name | polC |
| Synonyms | mutI, dnaF, dnaP |
| Essential | yes PubMed |
| Product | DNA polymerase III (alpha subunit) |
| Function | DNA replication |
| Interactions involving this protein in SubtInteract: PolC | |
| MW, pI | 162 kDa, 5.135 |
| Gene length, protein length | 4311 bp, 1437 aa |
| Immediate neighbours | proS, ylxS |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
DNA replication, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU16580
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)
- Protein family: PolC subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P13267
- KEGG entry: [2]
- E.C. number: 2.7.7.7
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
Glenn M Sanders, H Garry Dallmann, Charles S McHenry
Reconstitution of the B. subtilis replisome with 13 proteins including two distinct replicases.
Mol Cell: 2010, 37(2);273-81
[PubMed:20122408]
[WorldCat.org]
[DOI]
(I p)
Megan E Rokop, Jennifer M Auchtung, Alan D Grossman
Control of DNA replication initiation by recruitment of an essential initiation protein to the membrane of Bacillus subtilis.
Mol Microbiol: 2004, 52(6);1757-67
[PubMed:15186423]
[WorldCat.org]
[DOI]
(P p)
E Dervyn, C Suski, R Daniel, C Bruand, J Chapuis, J Errington, L Jannière, S D Ehrlich
Two essential DNA polymerases at the bacterial replication fork.
Science: 2001, 294(5547);1716-9
[PubMed:11721055]
[WorldCat.org]
[DOI]
(P p)
