Transcription factors of the GntR family

A large family of transcription factors. DNA-binding occurs via a winged helix-turn-helix motif and is mostly controlled by low molecular weight effectors. The family has four subfamilies, that differ in their effector-binding domains.

Members of the HutC subfamily in B. subtilis

• FrlR
• GmuR
• TreR
• YbgA
• YmfC
• YvoA
• YydK

Members of the YtrA subfamily in B. subtilis

• YhcF
• YtrA

Members of the FadR subfamily in B. subtilis

• YcbG

Members of the GntR subfamily in B. subtilis

• YdhC
• GntR

Additional GntR family regulator

• LutR

Transcription factors with a DNA-binding domain of the GntR family, but different effector-binding domain

• AraR

Reviews

Paul A Hoskisson, Sébastien Rigali
Chapter 1: Variation in form and function the helix-turn-helix regulators of the GntR superfamily.
Adv Appl Microbiol: 2009, 69;1-22
[PubMed:19729089] [WorldCat.org] [DOI] (P p)

Sébastien Rigali, Adeline Derouaux, Fabrizio Giannotta, Jean Dusart
Subdivision of the helix-turn-helix GntR family of bacterial regulators in the FadR, HutC, MocR, and YtrA subfamilies.
J Biol Chem: 2002, 277(15);12507-15
[PubMed:11756427] [WorldCat.org] [DOI] (P p)

D J Haydon, J R Guest
A new family of bacterial regulatory proteins.
FEMS Microbiol Lett: 1991, 63(2-3);291-5
[PubMed:2060763] [WorldCat.org] [DOI] (P p)