Difference between revisions of "GreA"
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * [[RNA polymerase]] accumulates in promoter-proximal regions of many genes {{PubMed|21515770}} | ||
=== Database entries === | === Database entries === | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' | + | * '''Interactions:''' [[GreA]]-[[RNA polymerase]] {{PubMed|21515770}} |
| − | * '''Localization:''' uniformly distributed throughout the nucleoid {{PubMed|16707701}} | + | * '''Localization:''' uniformly distributed throughout the nucleoid {{PubMed|16707701,21515770}} |
=== Database entries === | === Database entries === | ||
Revision as of 09:18, 26 April 2011
- Description: transcription elongation factor, resolves stalled RNA polymerase at promoter or promoter-proximal regions,
| Gene name | greA |
| Synonyms | |
| Essential | no |
| Product | transcription elongation factor |
| Function | transcription elongation |
| MW, pI | 17 kDa, 4.475 |
| Gene length, protein length | 471 bp, 157 aa |
| Immediate neighbours | pbpI, udk |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU27320
Phenotypes of a mutant
- RNA polymerase accumulates in promoter-proximal regions of many genes PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: greA/greB family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions: GreA-RNA polymerase PubMed
- Localization: uniformly distributed throughout the nucleoid PubMed
Database entries
- Structure:
- UniProt: P80240
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Padraig Deighan, Ann Hochschild
Conformational toggle triggers a modulator of RNA polymerase activity.
Trends Biochem Sci: 2006, 31(8);424-6
[PubMed:16815708]
[WorldCat.org]
[DOI]
(P p)
Sergei Borukhov, Jookyung Lee, Oleg Laptenko
Bacterial transcription elongation factors: new insights into molecular mechanism of action.
Mol Microbiol: 2005, 55(5);1315-24
[PubMed:15720542]
[WorldCat.org]
[DOI]
(P p)
Bryce E Nickels, Ann Hochschild
Regulation of RNA polymerase through the secondary channel.
Cell: 2004, 118(3);281-4
[PubMed:15294154]
[WorldCat.org]
[DOI]
(P p)
Original Publications
