Difference between revisions of "YjbH"

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* '''Cofactor(s):'''contains Zn atoms (coordinated by the N-terminal His-rich region) [http://www.ncbi.nlm.nih.gov/sites/entrez/19074380 PubMed]
 
* '''Cofactor(s):'''contains Zn atoms (coordinated by the N-terminal His-rich region) [http://www.ncbi.nlm.nih.gov/sites/entrez/19074380 PubMed]
  
* '''Effectors of protein activity:''' Zn atom is released upon treatment with strong oxidants [http://www.ncbi.nlm.nih.gov/sites/entrez/19074380 PubMed]
+
* '''Effectors of protein activity:'''  
 +
** Zn atom is released upon treatment with strong oxidants [http://www.ncbi.nlm.nih.gov/sites/entrez/19074380 PubMed]
 +
** interaction with [[YirB]] inhibits the formation of a complex with [[Spx]] {{PubMed|21378193}}
  
* '''Interactions:''' YjbH-[[Spx]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19074380 PubMed]
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* '''Interactions:'''  
 +
** [[YjbH]]-[[Spx]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19074380 PubMed]
 +
** [[YirB]]-[[YjbH]] {{PubMed|21378193}}
  
 
* '''Localization:''' cytosolic protein
 
* '''Localization:''' cytosolic protein
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=References=
 
=References=
  
==Reviews==
+
==Reviews: {{PubMed|19609260}}==
<pubmed>  19609260 </pubmed>
+
 
 
==Original Publications==
 
==Original Publications==
<pubmed>17293416,17908206,,19074380 17908206, </pubmed>
+
'''Additional publications:''' {{PubMed|21378193}}
 +
<pubmed>17293416, 19074380 17908206, </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 18:51, 28 March 2011

  • Description: adaptor protein for ClpX-ClpP-catalyzed Spx degradation, confers resistance against nitrosylating agents

Gene name yjbH
Synonyms
Essential no
Product adaptor protein
Function stimulation of Spx degradation
MW, pI 31 kDa, 5.206
Gene length, protein length 825 bp, 275 aa
Immediate neighbours pepF, yjbI
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YjbH context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

proteolysis

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU11550

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: adaptor protein for ClpX-ClpP-catalyzed Spx degradation PubMed
  • Protein family: UPF0413 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):contains Zn atoms (coordinated by the N-terminal His-rich region) PubMed
  • Effectors of protein activity:
    • Zn atom is released upon treatment with strong oxidants PubMed
    • interaction with YirB inhibits the formation of a complex with Spx PubMed
  • Localization: cytosolic protein

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Peter Zuber, Oregon Health and Science University, USA Homepage

Claes von Wachenfeldt, Lund University, Sweden Homepage

Your additional remarks

References

Reviews: PubMed

Original Publications

Additional publications: PubMed

Saurabh K Garg, Sushma Kommineni, Luke Henslee, Ying Zhang, Peter Zuber
The YjbH protein of Bacillus subtilis enhances ClpXP-catalyzed proteolysis of Spx.
J Bacteriol: 2009, 191(4);1268-77
[PubMed:19074380] [WorldCat.org] [DOI] (I p)

Jonas T Larsson, Annika Rogstam, Claes von Wachenfeldt
YjbH is a novel negative effector of the disulphide stress regulator, Spx, in Bacillus subtilis.
Mol Microbiol: 2007, 66(3);669-84
[PubMed:17908206] [WorldCat.org] [DOI] (P p)

Annika Rogstam, Jonas T Larsson, Peter Kjelgaard, Claes von Wachenfeldt
Mechanisms of adaptation to nitrosative stress in Bacillus subtilis.
J Bacteriol: 2007, 189(8);3063-71
[PubMed:17293416] [WorldCat.org] [DOI] (P p)