Difference between revisions of "RNA polymerase"

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===Other temporary components===
 
===Other temporary components===
 
* [[NusA]]: essential elongation factor
 
* [[NusA]]: essential elongation factor
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 +
==Back to [[protein-protein interactions]]==
  
 
==References==
 
==References==
 
===Reviews===
 
===Reviews===
 
<pubmed> 18599813 7708009 18410247 19889534 19489723 18280161 21233849 </pubmed>
 
<pubmed> 18599813 7708009 18410247 19889534 19489723 18280161 21233849 </pubmed>
 
 
===The structure of RNA polymerase===
 
===The structure of RNA polymerase===
 
<pubmed> 12732296 12581657 11297923 19735077 </pubmed>
 
<pubmed> 12732296 12581657 11297923 19735077 </pubmed>
 
===Important original publications: {{PubMed|20817769,20724389}} ===
 
===Important original publications: {{PubMed|20817769,20724389}} ===
 +
<pubmed> 21350489 </pubmed>

Revision as of 10:11, 27 February 2011

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The enzyme responsible for transcription

Components of the RNA polymerase

Core subunits

Sigma factors

  • In addition to the housekeeping sigma factor, SigA, there are several other sigma factors with different promoter recognition specifiity that are active under specific conditions (such as stress or sporulation)

Small accessory subunits

  • RpoE: delta subunit
  • YloH: omega subunit

Other temporary components

  • NusA: essential elongation factor

Back to protein-protein interactions

References

Reviews

Finn Werner, Dina Grohmann
Evolution of multisubunit RNA polymerases in the three domains of life.
Nat Rev Microbiol: 2011, 9(2);85-98
[PubMed:21233849] [WorldCat.org] [DOI] (I p)

Vladimir Svetlov, Evgeny Nudler
Macromolecular micromovements: how RNA polymerase translocates.
Curr Opin Struct Biol: 2009, 19(6);701-7
[PubMed:19889534] [WorldCat.org] [DOI] (I p)

Evgeny Nudler
RNA polymerase active center: the molecular engine of transcription.
Annu Rev Biochem: 2009, 78;335-61
[PubMed:19489723] [WorldCat.org] [DOI] (I p)

P J Lewis, G P Doherty, J Clarke
Transcription factor dynamics.
Microbiology (Reading): 2008, 154(Pt 7);1837-1844
[PubMed:18599813] [WorldCat.org] [DOI] (P p)

Kristina M Herbert, William J Greenleaf, Steven M Block
Single-molecule studies of RNA polymerase: motoring along.
Annu Rev Biochem: 2008, 77;149-76
[PubMed:18410247] [WorldCat.org] [DOI] (P p)

Sergei Borukhov, Evgeny Nudler
RNA polymerase: the vehicle of transcription.
Trends Microbiol: 2008, 16(3);126-34
[PubMed:18280161] [WorldCat.org] [DOI] (P p)

W G Haldenwang
The sigma factors of Bacillus subtilis.
Microbiol Rev: 1995, 59(1);1-30
[PubMed:7708009] [WorldCat.org] [DOI] (P p)

The structure of RNA polymerase

Important original publications: PubMed

Houra Merrikh, Cristina Machón, William H Grainger, Alan D Grossman, Panos Soultanas
Co-directional replication-transcription conflicts lead to replication restart.
Nature: 2011, 470(7335);554-7
[PubMed:21350489] [WorldCat.org] [DOI] (I p)