Difference between revisions of "GdpP"
| Line 71: | Line 71: | ||
* '''Domains:''' | * '''Domains:''' | ||
| + | ** N-terminal domain that shares minimum sequence homology with Per-ARNT-Sim (PAS) domains {{PubMed|21257773}} | ||
* '''Modification:''' | * '''Modification:''' | ||
| − | * '''Cofactor(s):''' | + | * '''Cofactor(s):''' b-type heme with 1:1 stoichiometry {{PubMed|21257773}} |
| − | * '''Effectors of protein activity:''' ppGpp inhibits cyclic dinucleotide phosphodiesterase activity {{PubMed|19901023}} | + | * '''Effectors of protein activity:''' |
| + | ** ppGpp inhibits cyclic dinucleotide phosphodiesterase activity {{PubMed|19901023}} | ||
| + | ** Heme binding suppresses phosphodiesterase activity {{PubMed|21257773}} | ||
* '''Interactions:''' | * '''Interactions:''' | ||
| Line 125: | Line 128: | ||
=References= | =References= | ||
| − | <pubmed> 19901023 </pubmed> | + | <pubmed> 19901023 21257773 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 07:36, 25 January 2011
- Description: cyclic dinucleotide phosphodiesterase, involved in stress signaling and response
| Gene name | yybT |
| Synonyms | |
| Essential | no |
| Product | cyclic dinucleotide phosphodiesterase |
| Function | unknown |
| MW, pI | 74 kDa, 4.865 |
| Gene length, protein length | 1977 bp, 659 aa |
| Immediate neighbours | rplI, yybS |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
metabolism of signalling nucleotides
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU40510
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: cyclic dinucleotide phosphodiesterase, hydrolysis of di-cyclic AMP PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- N-terminal domain that shares minimum sequence homology with Per-ARNT-Sim (PAS) domains PubMed
- Modification:
- Cofactor(s): b-type heme with 1:1 stoichiometry PubMed
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: P37484
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Feng Rao, Qiang Ji, Ishin Soehano, Zhao-Xun Liang
Unusual heme-binding PAS domain from YybT family proteins.
J Bacteriol: 2011, 193(7);1543-51
[PubMed:21257773]
[WorldCat.org]
[DOI]
(I p)
Feng Rao, Rui Yin See, Dongwei Zhang, Delon Chengxu Toh, Qiang Ji, Zhao-Xun Liang
YybT is a signaling protein that contains a cyclic dinucleotide phosphodiesterase domain and a GGDEF domain with ATPase activity.
J Biol Chem: 2010, 285(1);473-82
[PubMed:19901023]
[WorldCat.org]
[DOI]
(I p)
