Difference between revisions of "YycI"
| Line 80: | Line 80: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' forms dimers, [[YycH]]-[[YycI]] [http://www.ncbi.nlm.nih.gov/sites/entrez/17307850 PubMed] | + | * '''Interactions:''' forms dimers, [[YycH]]-[[YycI]] [http://www.ncbi.nlm.nih.gov/sites/entrez/17307850 PubMed], [[WalK]]-[[YycI]] {{PubMed|21219466}} |
| − | * '''Localization:''' cell membrane (according to Swiss-Prot) | + | * '''Localization:''' cell membrane (according to Swiss-Prot), spotty close to the membrane {{PubMed|21219466}} |
=== Database entries === | === Database entries === | ||
| Line 128: | Line 128: | ||
=References= | =References= | ||
| − | <pubmed>17307850,17350627,17307848,9829949,18408157,, </pubmed> | + | <pubmed>17307850,17350627,17307848,9829949,18408157,21219466, </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 10:14, 12 January 2011
- Description: negative effector of WalK, controls cell wall metabolism
| Gene name | yycI |
| Synonyms | |
| Essential | no |
| Product | negative effector of WalK |
| Function | control of cell wall metabolism |
| MW, pI | 32 kDa, 5.279 |
| Gene length, protein length | 840 bp, 280 aa |
| Immediate neighbours | walJ, yycH |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
cell wall/ other, transcription factors and their control, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU40380
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot), spotty close to the membrane PubMed
Database entries
- UniProt: Q45612
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation: expressed during vegetative growth, repressed during stationary phase PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Tatsuya Fukushima, Isako Furihata, Robyn Emmins, Richard A Daniel, James A Hoch, Hendrik Szurmant
A role for the essential YycG sensor histidine kinase in sensing cell division.
Mol Microbiol: 2011, 79(2);503-22
[PubMed:21219466]
[WorldCat.org]
[DOI]
(I p)
Hendrik Szurmant, Lintao Bu, Charles L Brooks, James A Hoch
An essential sensor histidine kinase controlled by transmembrane helix interactions with its auxiliary proteins.
Proc Natl Acad Sci U S A: 2008, 105(15);5891-6
[PubMed:18408157]
[WorldCat.org]
[DOI]
(I p)
Patrick D McLaughlin, Benjamin G Bobay, Erin J Regel, Richele J Thompson, James A Hoch, John Cavanagh
Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition.
FEBS Lett: 2007, 581(7);1425-9
[PubMed:17350627]
[WorldCat.org]
[DOI]
(P p)
Hendrik Szurmant, Michael A Mohan, P Michael Imus, James A Hoch
YycH and YycI interact to regulate the essential YycFG two-component system in Bacillus subtilis.
J Bacteriol: 2007, 189(8);3280-9
[PubMed:17307850]
[WorldCat.org]
[DOI]
(P p)
Eugenio Santelli, Robert C Liddington, Michael A Mohan, James A Hoch, Hendrik Szurmant
The crystal structure of Bacillus subtilis YycI reveals a common fold for two members of an unusual class of sensor histidine kinase regulatory proteins.
J Bacteriol: 2007, 189(8);3290-5
[PubMed:17307848]
[WorldCat.org]
[DOI]
(P p)
C Fabret, J A Hoch
A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy.
J Bacteriol: 1998, 180(23);6375-83
[PubMed:9829949]
[WorldCat.org]
[DOI]
(P p)
