Difference between revisions of "WalJ"
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| − | * '''Description:''' | + | * '''Description:''' coordination of cell division with DNA replication<br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Product''' || unknown | |style="background:#ABCDEF;" align="center"| '''Product''' || unknown | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || coordination of cell division with DNA replication |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.503 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.503 | ||
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * the mutant divides over unsegregated chromosomes more frequently than wild-type cells, and this phenotype is exacerbated when DNA replication is inhibited {{PubMed|21169496}} | ||
| + | * increased sensitivity to a narrow spectrum of cephalosporin antibiotics {{PubMed|21169496}} | ||
=== Database entries === | === Database entries === | ||
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=== Additional information=== | === Additional information=== | ||
| − | |||
| − | |||
| − | |||
=The protein= | =The protein= | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' | + | * '''Catalyzed reaction/ biological activity:''' the enzymatic activity of WalJ directly or indirectly affects cell wall metabolism and is required for accurate coordination of cell division with DNA replication {{PubMed|21169496}} |
| − | * '''Protein family:''' | + | * '''Protein family:''' predicted member of the metallo-β-lactamase superfamily |
* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
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=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' ''[[walR]]-[[walK]]-[[yycH]]-[[yycI]]-[[ | + | * '''Operon:''' ''[[walR]]-[[walK]]-[[yycH]]-[[yycI]]-[[walJ]]-[[yyxA]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/9829949 PubMed] |
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
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<pubmed>9829949,, </pubmed> | <pubmed>9829949,, </pubmed> | ||
| − | Additional publications: {{PubMed|21169496}} | + | '''Additional publications:''' {{PubMed|21169496}} |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 10:52, 23 December 2010
- Description: coordination of cell division with DNA replication
| Gene name | yycJ |
| Synonyms | |
| Essential | no |
| Product | unknown |
| Function | coordination of cell division with DNA replication |
| MW, pI | 29 kDa, 5.503 |
| Gene length, protein length | 804 bp, 268 aa |
| Immediate neighbours | yyxA, yycI |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU40370
Phenotypes of a mutant
- the mutant divides over unsegregated chromosomes more frequently than wild-type cells, and this phenotype is exacerbated when DNA replication is inhibited PubMed
- increased sensitivity to a narrow spectrum of cephalosporin antibiotics PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: the enzymatic activity of WalJ directly or indirectly affects cell wall metabolism and is required for accurate coordination of cell division with DNA replication PubMed
- Protein family: predicted member of the metallo-β-lactamase superfamily
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: C0SP91
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation: expressed during vegetative growth, repressed during stationary phase PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
C Fabret, J A Hoch
A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy.
J Bacteriol: 1998, 180(23);6375-83
[PubMed:9829949]
[WorldCat.org]
[DOI]
(P p)
Additional publications: PubMed
