RelA

• Description: GTP pyrophosphokinase (stringent response)
  
  

Gene name	relA
Synonyms
Essential	no
Product	GTP pyrophosphokinase
Function	synthesis and degradation of (p)ppGpp, triggering the stringent response
Metabolic function and regulation of this protein in SubtiPathways: Purine salvage, Nucleotides (regulation), Murein recycling
MW, pI	84 kDa, 6.964
Gene length, protein length	2202 bp, 734 aa
Immediate neighbours	yrvI, apt
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

metabolism of signalling nucleotides

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

• Locus tag: BSU27600

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate (according to Swiss-Prot)

• Protein family: relA/spoT family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O54408

• KEGG entry: [3]

• E.C. number: 2.7.6.5

Expression and regulation

• Operon: relA-yrvI PubMed

• Sigma factor: SigB PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Mohamed Marahiel, Marburg University, Germany homepage