CodV

• Description: site-specific integrase/recombinase
  
  

Gene name	codV
Synonyms
Essential	no
Product	site-specific integrase/recombinase
Function	chromosome partitioning
MW, pI	35 kDa, 9.31
Gene length, protein length	912 bp, 304 aa
Immediate neighbours	trmFO, clpQ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

DNA condensation/ segregation

This gene is a member of the following regulons

CodY regulon

The gene

Basic information

• Locus tag: BSU16140

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: XerC subfamily (according to Swiss-Prot)

• Paralogous protein(s): RipX

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P39776

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: codV-clpQ-clpY-codY PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

• Regulatory mechanism:
  • CodY: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Alexandra E Bloor, Rocky M Cranenburgh
An efficient method of selectable marker gene excision by Xer recombination for gene replacement in bacterial chromosomes.
Appl Environ Microbiol: 2006, 72(4);2520-5
[PubMed:16597952] [WorldCat.org] [DOI] (P p)

M Ratnayake-Lecamwasam, P Serror, K W Wong, A L Sonenshein
Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels.
Genes Dev: 2001, 15(9);1093-103
[PubMed:11331605] [WorldCat.org] [DOI] (P p)

S A Sciochetti, P J Piggot, G W Blakely
Identification and characterization of the dif Site from Bacillus subtilis.
J Bacteriol: 2001, 183(3);1058-68
[PubMed:11208805] [WorldCat.org] [DOI] (P p)

S A Sciochetti, P J Piggot, D J Sherratt, G Blakely
The ripX locus of Bacillus subtilis encodes a site-specific recombinase involved in proper chromosome partitioning.
J Bacteriol: 1999, 181(19);6053-62
[PubMed:10498718] [WorldCat.org] [DOI] (P p)

F J Slack, P Serror, E Joyce, A L Sonenshein
A gene required for nutritional repression of the Bacillus subtilis dipeptide permease operon.
Mol Microbiol: 1995, 15(4);689-702
[PubMed:7783641] [WorldCat.org] [DOI] (P p)