GroES

• Description: chaperonin, universally conserved protein
  
  

Gene name	groES
Synonyms
Essential	yes PubMed
Product	chaperonin
Function	protein folding and re-folding
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	10 kDa, 4.595
Gene length, protein length	282 bp, 94 aa
Immediate neighbours	ydiL, groEL
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

chaperones/ protein folding, heat shock proteins, essential genes, universally conserved proteins

This gene is a member of the following regulons

HrcA regulon

The gene

Basic information

• Locus tag: BSU06020

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: groES chaperonin family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on Ser-36 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions: GroEL-GroES

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P28599

• KEGG entry: [3]

• E.C. number:

Additional information

universally conserved protein

Expression and regulation

• Operon: groES-groEL PubMed

• Sigma factor: SigA PubMed

• Regulation: induced by heat shock (HrcA) PubMed

• Regulatory mechanism: HrcA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Wolfgang Schumann, Bayreuth University, Germany Homepage