Difference between revisions of "RsbT"

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= [[Categories]] containing this gene/protein =
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{{SubtiWiki category|[[protein modification]]}},
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=The gene=
 
=The gene=
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= Categories containing this gene/protein =
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{{SubtiWiki category|[[protein modification]]}},
 
{{SubtiWiki category|[[sigma factors and their control]]}}
 
 
=The protein=
 
=The protein=
  

Revision as of 16:58, 8 December 2010

Gene name rsbT
Synonyms ycxT
Essential no
Product PP2C activator, protein serine kinase
Function control of SigB activity
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 14 kDa, 6.587
Gene length, protein length 399 bp, 133 aa
Immediate neighbours rsbS, rsbU
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
RsbT context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

protein modification, sigma factors and their control

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU04690

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + a protein = ADP + a phosphoprotein (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure: 3VY9 (complete stressosome)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: constitutively expressed PubMed
  • Regulatory mechanism:
  • Additional information:
    • RsbT is synthesized at the same rate as RsbRA and RsbS, however, the RsbT level in growing B. subtilis is only 10% that of RsbRA, suggesting that the protein is unstable PubMed.

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Jon Marles-Wright, Richard J Lewis
The stressosome: molecular architecture of a signalling hub.
Biochem Soc Trans: 2010, 38(4);928-33
[PubMed:20658979] [WorldCat.org] [DOI] (I p)

Jon Marles-Wright, Richard J Lewis
The Bacillus subtilis stressosome: A signal integration and transduction hub.
Commun Integr Biol: 2008, 1(2);182-4
[PubMed:19704888] [WorldCat.org] [DOI] (I p)

Jan Pané-Farré, Richard J Lewis, Jörg Stülke
The RsbRST stress module in bacteria: a signalling system that may interact with different output modules.
J Mol Microbiol Biotechnol: 2005, 9(2);65-76
[PubMed:16319496] [WorldCat.org] [DOI] (P p)


Original Articles