Difference between revisions of "SlrA"

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This gene was only recently identified. [http://www.ncbi.nlm.nih.gov/sites/entrez/18647168 PubMed]
 
This gene was only recently identified. [http://www.ncbi.nlm.nih.gov/sites/entrez/18647168 PubMed]
  
 +
 +
= Categories containing this gene/protein =
 +
{{SubtiWiki category|[[transcription factors and their control]]}},
 +
{{SubtiWiki category|[[transition state regulators]]}},
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{{SubtiWiki category|[[biofilm formation]]}}
 
=The protein=
 
=The protein=
  

Revision as of 20:00, 30 November 2010

  • Description: anti-repressor, antagonist of SinR and SlrR, involved in control of flagellar genes and eps and yqxM-sipW-tasA operons

Gene name slrA
Synonyms
Essential no
Product antagonist of SinR and SlrR
Function control of biofilm formation
Regulation of this protein in SubtiPathways:
Biofilm
MW, pI xx,x kDa, y.yy
Gene length, protein length 156 bp, 52 aa
Immediate neighbours ywcC, ywcB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YwcC context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag:

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry:

Additional information

This gene was only recently identified. PubMed


Categories containing this gene/protein

transcription factors and their control, transition state regulators, biofilm formation

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: binding of SinR resulting in induction of SinR-repressed genes and operons PubMed
  • Protein family:
  • Paralogous protein(s): SinI

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: SlrR inhibits activity of SlrA (i. e. binding to SinR) PubMed
  • Localization:

Database entries

  • Structure:
  • KEGG entry: no entry
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system: B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Stülke lab
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Yunrong Chai, Roberto Kolter, Richard Losick
Paralogous antirepressors acting on the master regulator for biofilm formation in Bacillus subtilis.
Mol Microbiol: 2009, 74(4);876-87
[PubMed:19788541] [WorldCat.org] [DOI] (I p)

Kazuo Kobayashi
SlrR/SlrA controls the initiation of biofilm formation in Bacillus subtilis.
Mol Microbiol: 2008, 69(6);1399-410
[PubMed:18647168] [WorldCat.org] [DOI] (I p)