LytS

• Description: two-component sensor kinase, regulation of rate of autolysis
  
  

Gene name	lytS
Synonyms
Essential	no
Product	two-component sensor kinase
Function	regulation of the rate of autolysis
MW, pI	64 kDa, 8.241
Gene length, protein length	1779 bp, 593 aa
Immediate neighbours	lytT, ysaA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU28930

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

cell wall degradation/ turnover, protein modification, transcription factors and their control, membrane proteins, phosphoproteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + LytT = ADP + LytT-P

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: 5 transmembrane regions

• Modification: autophosphorylation on a His residue

• Cofactor(s):

• Effectors of protein activity:

• Interactions: LytT-LytS

• Localization: membrane (putative, due to presence of 5 membrane-spanning domains)

Database entries

• Structure:

• UniProt: P94513

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672] [WorldCat.org] [DOI] (P p)